Özgür Balasar1, Tuğrul Çakır2, Özgür Erkal3, Arif Aslaner4, Bülent Çekiç5, Mehmet Uyar6, Nurullah Bülbüller4, Mehmet Tahir Oruç4. 1. Department of Medical Genetics, Dr. Faruk Sükan Maternity and Pediatric Hospital, Konya, Turkey. 2. General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey. tugrul-cakir@hotmail.com. 3. Department of Medical Genetics, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey. 4. General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey. 5. Radiology Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey. 6. Department of Public Health, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Abstract
PURPOSE: Remarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for LSG. MATERIALS AND METHODS: All individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month. RESULTS: Twenty-eight patients (37.8%) had genotype TT (wild-type allel), 36 patients (48.6%) had genotype TA, and 10 patients (13.5%) had genotype AA. In both wild-type group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG. CONCLUSION: Our data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.
PURPOSE: Remarkable differences in weight loss have been observed in obesepatients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609FTO gene polymorphism on weight loss among severely obesepatients applying for LSG. MATERIALS AND METHODS: All individuals were analyzed for the FTOrs9939609 gene polymorphism. A total of 74 morbid obesepatients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month. RESULTS: Twenty-eight patients (37.8%) had genotype TT (wild-type allel), 36 patients (48.6%) had genotype TA, and 10 patients (13.5%) had genotype AA. In both wild-type group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG. CONCLUSION: Our data showed that the rs9939609FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obesepatients in short-term follow-up.
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