INTRODUCTION: The aim of this study was to analyze the effects of the rs9939609 (T/A) gene variant in fat mass and obesity-associated gene (FTO) on body weight changes after 3 years and its modification by a randomized nutritional intervention with a Mediterranean-style diet in a population of subjects at high cardiovascular risk. DESIGN: A substudy of PREDIMED, which is a randomized trial aimed at assessing the effect of the Mediterranean diet (MD) for primary cardiovascular disease prevention. There were three nutritional intervention groups: two of them with a Mediterranean-style diet and the third was a control group advised to follow a conventional low-fat diet. SUBJECTS: A total of 776 high cardiovascular risk subjects aged 55-80 years. MEASUREMENTS: Anthropometric measurements were recorded at baseline and at 3 years. The participants were genotyped by RT-PCR, followed by allelic discrimination. RESULTS: Homozygous subjects had the highest baseline body weight. The dominant model showed that subjects carrying the A allele had the lowest body weight gain (B=-0.685; P=0.022) after 3 years of nutritional intervention compared with nonmutated subjects (TT genotype) regardless of the nutritional intervention. Moreover, this effect was statistically significant in carriers of the A allele only among those allocated to the MD groups (B=-0.830; P=0.018), but it was not significant among those allocated to the control group (P for interaction=0.649). CONCLUSION: This study confirmed the association between body weight and the FTO rs9939609 polymorphism. Interestingly, our results showed that, although at baseline the A allele was associated with higher body weight, after 3 years of nutritional intervention with a Mediterranean-style-diet, A-allele carriers had lower body weight gain than wild type subjects. No interaction between nutritional intervention and the polymorphism was found.
RCT Entities:
INTRODUCTION: The aim of this study was to analyze the effects of the rs9939609 (T/A) gene variant in fat mass and obesity-associated gene (FTO) on body weight changes after 3 years and its modification by a randomized nutritional intervention with a Mediterranean-style diet in a population of subjects at high cardiovascular risk. DESIGN: A substudy of PREDIMED, which is a randomized trial aimed at assessing the effect of the Mediterranean diet (MD) for primary cardiovascular disease prevention. There were three nutritional intervention groups: two of them with a Mediterranean-style diet and the third was a control group advised to follow a conventional low-fat diet. SUBJECTS: A total of 776 high cardiovascular risk subjects aged 55-80 years. MEASUREMENTS: Anthropometric measurements were recorded at baseline and at 3 years. The participants were genotyped by RT-PCR, followed by allelic discrimination. RESULTS: Homozygous subjects had the highest baseline body weight. The dominant model showed that subjects carrying the A allele had the lowest body weight gain (B=-0.685; P=0.022) after 3 years of nutritional intervention compared with nonmutated subjects (TT genotype) regardless of the nutritional intervention. Moreover, this effect was statistically significant in carriers of the A allele only among those allocated to the MD groups (B=-0.830; P=0.018), but it was not significant among those allocated to the control group (P for interaction=0.649). CONCLUSION: This study confirmed the association between body weight and the FTOrs9939609 polymorphism. Interestingly, our results showed that, although at baseline the A allele was associated with higher body weight, after 3 years of nutritional intervention with a Mediterranean-style-diet, A-allele carriers had lower body weight gain than wild type subjects. No interaction between nutritional intervention and the polymorphism was found.
Authors: Daniel Antonio de Luis; Rocío Aller; Rosa Conde; Olatz Izaola; David Pacheco; Manuel Gonzalez Sagrado; David Primo Journal: J Gastrointest Surg Date: 2012-02-04 Impact factor: 3.452
Authors: William S Garver; Sara B Newman; Diana M Gonzales-Pacheco; Joseph J Castillo; David Jelinek; Randall A Heidenreich; Robert A Orlando Journal: Genes Nutr Date: 2013-03-08 Impact factor: 5.523
Authors: Roseann E Peterson; Hermine H Maes; Peter Holmans; Alan R Sanders; Douglas F Levinson; Jianxin Shi; Kenneth S Kendler; Pablo V Gejman; Bradley T Webb Journal: Hum Genet Date: 2010-11-23 Impact factor: 4.132