| Literature DB >> 22304713 |
C A Foss1, R C Mease, S Y Cho, H J Kim, M G Pomper.
Abstract
Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.Entities:
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Year: 2012 PMID: 22304713 PMCID: PMC4076792 DOI: 10.2174/092986712799462612
Source DB: PubMed Journal: Curr Med Chem ISSN: 0929-8673 Impact factor: 4.530