Literature DB >> 22295155

Lymphoepithelioma-like carcinoma of the colon.

David Delaney1, Runjan Chetty.   

Abstract

An 85-year old female had a polypoid tumour in the sigmoid colon that histologically conformed to a lymphoepithelioma-like (LEL) carcinoma. The tumour was arranged in cords, chains, clusters and microalveoli of pleomorphic, irregular cells set within a dense intratumoral lymphocytic stroma. The tumour was EBV-negative and showed loss of MLH-1 and PMS-2 mismatch repair proteins. The patient did not fulfil the criteria for HNPCC. Only 5 other cases of primary colonic LEL carcinoma have been described previously and only one case appears to have an unequivocal association with EBV. In addition, one of the cases was encountered in a HNPCC patient. This is an unusual morphologic variant of a microsatellite unstable tumour with a LEL pattern, not associated with EBV.

Entities:  

Keywords:  EBV; Lymphoepithelioma-like carcinoma; intratumoral lymphocytes; medullary carcinoma; microsatellite instability; mismatch repair proteins

Mesh：

Year:  2012        PMID： 22295155      PMCID： PMC3267494     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  29 in total

1.  Lymphoepithelioma-like carcinoma of rectum: possible relation with EBV.

Authors:  S Kon; K Kasai; N Tsuzuki; M Nishibe; T Kitagawa; T Nishibe; N Sato
Journal:  Pathol Res Pract       Date:  2001       Impact factor: 3.250

Review 2.  Epstein-Barr virus and gastric carcinoma.

Authors:  K Takada
Journal:  Mol Pathol       Date:  2000-10

3.  Epstein-Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: a study in one area of Chile.

Authors:  A Corvalan; C Koriyama; S Akiba; Y Eizuru; C Backhouse; M Palma; J Argandoña; M Tokunaga
Journal:  Int J Cancer       Date:  2001-11       Impact factor: 7.396

4.  A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis.

Authors:  Yasuyuki Kojima; Masatoshi Mogaki; Ryo Takagawa; Ikuko Ota; Mitsutaka Sugita; Shiho Natori; Yohei Hamaguchi; Haruki Kurosawa; Tadao Fukushima; Hidenobu Masui; Shingo Fukazawa; Shoji Yamanaka; Yukio Tsuura; Kaoru Nagahori
Journal:  J Gastroenterol       Date:  2007-03-12       Impact factor: 7.527

5.  Epstein-Barr virus and gastric carcinoma in Western patients: comparison of pathological parameters and p53 expression in EBV-positive and negative tumours.

Authors:  F Chapel; B Fabiani; F Davi; M Raphael; M Tepper; G Champault; C Guettier
Journal:  Histopathology       Date:  2000-03       Impact factor: 5.087

6.  Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma.

Authors:  Gyeong Hoon Kang; Sun Lee; Woo Ho Kim; Hye Won Lee; Jin Cheon Kim; Mun-Gan Rhyu; Jae Y Ro
Journal:  Am J Pathol       Date:  2002-03       Impact factor: 4.307

7.  Lymphocyte-rich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival.

Authors:  Karen L Grogg; Christine M Lohse; V Shane Pankratz; Kevin C Halling; Thomas C Smyrk
Journal:  Mod Pathol       Date:  2003-07       Impact factor: 7.842

8.  Gastric carcinoma with lymphoid stroma: incidence of EBV and Helicobacter pylori infection.

Authors:  Hye Jae Cho; Jung Yeon Kim; Jinye Yoo; Sang Sook Lee
Journal:  Appl Immunohistochem Mol Morphol       Date:  2003-06

9.  EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement.

Authors:  Josine van Beek; Axel zur Hausen; Elma Klein Kranenbarg; Cornelis J H van de Velde; Jaap M Middeldorp; Adriaan J C van den Brule; Chris J L M Meijer; Elisabeth Bloemena
Journal:  J Clin Oncol       Date:  2004-02-15       Impact factor: 44.544

10.  Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation.

Authors:  Q N Vo; J Geradts; M L Gulley; D A Boudreau; J C Bravo; B G Schneider
Journal:  J Clin Pathol       Date:  2002-09       Impact factor: 3.411
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  6 in total

1.  HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil.

Authors:  Pallavi Kopparthy; Joanna Chaffin; Michael M Feely; Hiral D Parekh
Journal:  Clin J Gastroenterol       Date:  2021-02-19

2.  A case of Lymphoepithelioma-like carcinoma (LELC) developed in the rectum.

Authors:  Haruka Oi; Satoshi Yamamoto; Yoshiharu Kono; Yukiyoshi Masaki
Journal:  Rep Pract Oncol Radiother       Date:  2019-10-29

3.  Lymphoepithelioma-like carcinoma of the colon.

Authors:  Yasuharu Mori; Kazunari Akagi; Masaaki Yano; Hiroshi Sashiyama; Osamu Tsutsumi; Yukihiro Hamahata; Yasunobu Tsujinaka; Akihiko Tsuchida; Jun Matsubayashi
Journal:  Case Rep Gastroenterol       Date:  2013-03-13

4.  A case of poorly differentiated adenocarcinoma with lymphoid stroma originated in the ascending colon diagnosed as lymphoepithelioma-like carcinoma.

Authors:  Kengo Kai; Hideki Hidaka; Takeshi Nakamura; Yuji Ueda; Kosuke Marutsuka; Takuto Ikeda; Atsushi Nanashima
Journal:  Clin J Gastroenterol       Date:  2019-12-16

5.  A Rare Case of Moderately Differentiated Adenocarcinoma With PD-L1 Overexpression and a Heterogeneous LELC Component in the Ascending Colon.

Authors:  Hideki Nagano; Takeshi Watanabe; Tamotsu Togawa; Kenji Ohnishi; Toshihisa Kimura; Atsushi Iida; Yasunori Sato; Takanori Goi
Journal:  Onco Targets Ther       Date:  2020-01-28       Impact factor: 4.147

Review 6.  Epstein-Barr Virus in the Development of Colorectal Cancer (Review).

Authors:  N A Oleynikova; N V Danilova; M O Grimuta; P G Malkov
Journal:  Sovrem Tekhnologii Med       Date:  2021-08-28
  6 in total

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