Literature DB >> 22282719

A sensitive near-infrared fluorescent probe for caspase-mediated apoptosis: Synthesis and application in cell imaging.

Yepeng Luan1, Qiuhong Yang, Yumei Xie, Shaofeng Duan, Shuang Cai, M L Forrest.   

Abstract

Near-infrared (NIR) absorbing dyes represent an intriguing avenue for extracting biological information from living subjects since they can be monitored with noninvasive optical imaging techniques. We designed and synthesized an imaging agent which contains a NIR fluorochrome (IR780) and peptidyl fluoromethyl ketone (FMK) for caspase-9 imaging of cells undergoing apoptosis. The IR780-FMK fluorescent probe had a Strokes shift of 79 nm and quantum yield 0.75. Prostate cancer DU145 cells undergoing apoptosis were successfully imaged using as little as 0.1 μM of IR780-FMK.

Entities:  

Year:  2011        PMID： 22282719      PMCID： PMC3265084          DOI： 10.5582/ddt.2011.v5.5.220

Source DB:  PubMed          Journal:  Drug Discov Ther        ISSN： 1881-7831


  23 in total

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Journal:  Bioconjug Chem       Date:  2008-05       Impact factor: 4.774
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  3 in total

Review 1.  Small Molecule Active Site Directed Tools for Studying Human Caspases.

Authors:  Marcin Poreba; Aleksandra Szalek; Paulina Kasperkiewicz; Wioletta Rut; Guy S Salvesen; Marcin Drag
Journal:  Chem Rev       Date:  2015-11-09       Impact factor: 60.622

2.  In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe.

Authors:  Qiuhong Yang; Huizhong Cui; Shuang Cai; Xinmai Yang; M Laird Forrest
Journal:  J Biomed Opt       Date:  2011-11       Impact factor: 3.170

Review 3.  Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications.

Authors:  Carissa M Lloyd; Neil Colgin; Steven L Cobb
Journal:  Molecules       Date:  2020-11-28       Impact factor: 4.411
  3 in total

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