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Literature DB >> 22280462

Chlorinated englerins with selective inhibition of renal cancer cell growth.

Rhone K Akee¹, Tanya Ransom, Ranjala Ratnayake, James B McMahon, John A Beutler.

Abstract

The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).

Entities: Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 22280462 PMCID： PMC3311709 DOI： 10.1021/np200905u

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

9 in total

1. Asymmetric, protecting-group-free total synthesis of (-)-englerin A.

Authors: Qianghui Zhou; Xiaofei Chen; Dawei Ma
Journal: Angew Chem Int Ed Engl Date: 2010-05-03 Impact factor: 15.336

2. Enantioselective synthesis of (-)-englerins A and B.

Authors: Kian Molawi; Nicolas Delpont; Antonio M Echavarren
Journal: Angew Chem Int Ed Engl Date: 2010-05-03 Impact factor: 15.336

3. Chemical synthesis and biological evaluation of the englerin analogues.

Authors: Kok Ping Chan; David Y-K Chen
Journal: ChemMedChem Date: 2011-01-18 Impact factor: 3.466

4. Total synthesis and absolute configuration of the guaiane sesquiterpene englerin A.

Authors: Matthieu Willot; Lea Radtke; Daniel Könning; Roland Fröhlich; Viktoria H Gessner; Carsten Strohmann; Mathias Christmann
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

Review 5. The NCI60 human tumour cell line anticancer drug screen.

Authors: Robert H Shoemaker
Journal: Nat Rev Cancer Date: 2006-10 Impact factor: 60.716

6. A brief synthesis of (-)-englerin A.

Authors: Zhenwu Li; Mika Nakashige; William J Chain
Journal: J Am Chem Soc Date: 2011-04-08 Impact factor: 15.419

7. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Authors: Ranjala Ratnayake; David Covell; Tanya T Ransom; Kirk R Gustafson; John A Beutler
Journal: Org Lett Date: 2009-01-01 Impact factor: 6.005

8. Total synthesis of englerin A.

Authors: K C Nicolaou; Qiang Kang; Sin Yee Ng; David Y-K Chen
Journal: J Am Chem Soc Date: 2010-06-16 Impact factor: 15.419

9. High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

Authors: Thomas G McCloud
Journal: Molecules Date: 2010-06-24 Impact factor: 4.411

9 in total

7 in total

1. Synthesis of a stable and orally bioavailable englerin analogue.

Authors: David M Fash; Cody J Peer; Zhenwu Li; Ian J Talisman; Sima Hayavi; Florian J Sulzmaier; Joe W Ramos; Carole Sourbier; Leonard Neckers; W Douglas Figg; John A Beutler; William J Chain
Journal: Bioorg Med Chem Lett Date: 2016-04-08 Impact factor: 2.823

Review 2. Englerins: A Comprehensive Review.

Authors: Zhenhua Wu; Senzhi Zhao; David M Fash; Zhenwu Li; William J Chain; John A Beutler
Journal: J Nat Prod Date: 2017-02-07 Impact factor: 4.050

3. Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-(ω-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines.

Authors: Michele Tonelli; Bruno Tasso; Lorenzo Mina; Giuseppe Paglietti; Vito Boido; Fabio Sparatore
Journal: Mol Divers Date: 2013-04-13 Impact factor: 2.943