Literature DB >> 28170253

Englerins: A Comprehensive Review.

Zhenhua Wu1, Senzhi Zhao1, David M Fash1, Zhenwu Li1, William J Chain1, John A Beutler2.   

Abstract

In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.

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Year:  2017        PMID： 28170253      PMCID： PMC6198806          DOI： 10.1021/acs.jnatprod.6b01167

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  67 in total

1.  Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

Authors:  Melissa Miller; Jie Shi; Yingmin Zhu; Maksym Kustov; Jin-bin Tian; Amy Stevens; Meng Wu; Jia Xu; Shunyou Long; Pu Yang; Alexander V Zholos; James M Salovich; C David Weaver; Corey R Hopkins; Craig W Lindsley; Owen McManus; Min Li; Michael X Zhu
Journal:  J Biol Chem       Date:  2011-07-27       Impact factor: 5.157

2.  Total synthesis and absolute configuration of the guaiane sesquiterpene englerin A.

Authors:  Matthieu Willot; Lea Radtke; Daniel Könning; Roland Fröhlich; Viktoria H Gessner; Carsten Strohmann; Mathias Christmann
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 3.  TRPC4- and TRPC4-containing channels.

Authors:  Marc Freichel; Volodymyr Tsvilovskyy; Juan E Camacho-Londoño
Journal:  Handb Exp Pharmacol       Date:  2014

Review 4.  Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death.

Authors:  Amnon Altman; Martin Villalba
Journal:  J Biochem       Date:  2002-12       Impact factor: 3.387

5.  From Complex Natural Products to Simple Synthetic Mimetics by Computational De Novo Design.

Authors:  Lukas Friedrich; Tiago Rodrigues; Claudia S Neuhaus; Petra Schneider; Gisbert Schneider
Journal:  Angew Chem Int Ed Engl       Date:  2016-04-25       Impact factor: 15.336

Review 6.  The NCI60 human tumour cell line anticancer drug screen.

Authors:  Robert H Shoemaker
Journal:  Nat Rev Cancer       Date:  2006-10       Impact factor: 60.716

7.  Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms.

Authors:  Marjan Hezareh; Moulay Ahmed Moukil; Ildiko Szanto; Malgorzata Pondarzewski; Sarah Mouche; Nathalie Cherix; Stephen J Brown; Jean-Louis Carpentier; Michelangelo Foti
Journal:  Antivir Chem Chemother       Date:  2004-07

8.  PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis.

Authors:  Karine Belguise; Gail E Sonenshein
Journal:  J Clin Invest       Date:  2007-12       Impact factor: 14.808

9.  Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

Authors:  Cheryl Carson; Pichai Raman; Jennifer Tullai; Lei Xu; Martin Henault; Emily Thomas; Sarita Yeola; Jianmin Lao; Mark McPate; J Martin Verkuyl; George Marsh; Jason Sarber; Adam Amaral; Scott Bailey; Danuta Lubicka; Helen Pham; Nicolette Miranda; Jian Ding; Hai-Ming Tang; Haisong Ju; Pamela Tranter; Nan Ji; Philipp Krastel; Rishi K Jain; Andrew M Schumacher; Joseph J Loureiro; Elizabeth George; Giuliano Berellini; Nathan T Ross; Simon M Bushell; Gül Erdemli; Jonathan M Solomon
Journal:  PLoS One       Date:  2015-06-22       Impact factor: 3.240

Review 10.  Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.

Authors:  Hannah J Gaunt; Naveen S Vasudev; David J Beech
Journal:  Eur Biophys J       Date:  2016-06-11       Impact factor: 1.733
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  17 in total

1.  Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.

Authors:  Corena V Grant; Chase M Carver; Shayne D Hastings; Karthik Ramachandran; Madesh Muniswamy; April L Risinger; John A Beutler; Susan L Mooberry
Journal:  Breast Cancer Res Treat       Date:  2019-06-22       Impact factor: 4.872

2.  Importance of a 4-Alkyl Substituent for Activity in the Englerin Series.

Authors:  Daniel C Elliott; John A Beutler; Kathlyn A Parker
Journal:  ACS Med Chem Lett       Date:  2017-06-06       Impact factor: 4.345

Review 3.  Treasure troves of pharmacological tools to study transient receptor potential canonical 1/4/5 channels.

Authors:  Hussein N Rubaiy
Journal:  Br J Pharmacol       Date:  2019-03-06       Impact factor: 8.739

4.  Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Authors:  Hussein N Rubaiy; Tobias Seitz; Sven Hahn; Axel Choidas; Peter Habenberger; Bert Klebl; Klaus Dinkel; Peter Nussbaumer; Herbert Waldmann; Mathias Christmann; David J Beech
Journal:  Br J Pharmacol       Date:  2018-01-25       Impact factor: 8.739

5.  Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels.

Authors:  Hussein N Rubaiy; Melanie J Ludlow; Karsten Siems; Katherine Norman; Richard Foster; Dietmar Wolf; John A Beutler; David J Beech
Journal:  Br J Pharmacol       Date:  2018-06-28       Impact factor: 8.739

6.  Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition.

Authors:  Zhenhua Wu; Jean-Simon Suppo; Sarka Tumova; Jonathan Strope; Fernando Bravo; Melody Moy; Ethan S Weinstein; Cody J Peer; William D Figg; William J Chain; Antonio M Echavarren; David J Beech; John A Beutler
Journal:  ACS Med Chem Lett       Date:  2020-08-03       Impact factor: 4.345

Review 7.  Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials.

Authors:  Yuan-Yuan Gao; Wen Tian; Hui-Nan Zhang; Yang Sun; Jing-Ru Meng; Wei Cao; Xiao-Qiang Li
Journal:  Arch Pharm Res       Date:  2021-03-24       Impact factor: 4.946

Review 8.  Natural products targeting cancer cell dependency.

Authors:  Changxiang Shi; Eun Ju Yang; Shishi Tao; Guowen Ren; Pui Kei Mou; Joong Sup Shim
Journal:  J Antibiot (Tokyo)       Date:  2021-06-23       Impact factor: 2.649

9.  Identification of natural product modulators of Merkel cell carcinoma cell growth and survival.

Authors:  Emily A Smith; Natasha T Hill; Tara Gelb; Khalid A Garman; Ekaterina I Goncharova; Heidi R Bokesch; Chang-Kwon Kim; Karen L Wendt; Robert H Cichewicz; Kirk R Gustafson; Isaac Brownell; Curtis J Henrich
Journal:  Sci Rep       Date:  2021-06-30       Impact factor: 4.996

10.  (-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5.

Authors:  João de Sousa Valente; Khadija M Alawi; Sabah Bharde; Ali A Zarban; Xenia Kodji; Dibesh Thapa; Fulye Argunhan; Brentton Barrett; Istvan Nagy; Susan D Brain
Journal:  Int J Mol Sci       Date:  2021-06-15       Impact factor: 5.923
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