Literature DB >> 22274929

Challenging a classic myth: pneumoperitoneum associated with acute diverticulitis is not an indication for open or laparoscopic emergency surgery in hemodynamically stable patients. A 10-year experience with a nonoperative treatment.

Renato Costi1, François Cauchy, Alban Le Bian, Jean-François Honart, Nicolas Creuze, Claude Smadja.   

Abstract

BACKGROUND: In patients presenting with acute diverticulitis (AD) and signs of acute peritonitis, the presence of extradigestive air (EDA) on a computer tomography (CT) scan is often considered to indicate the need for emergency surgery. Although the traditional management of "perforated" AD is open sigmoidectomy, more recently, laparoscopic drainage/lavage (usually followed by delayed elective sigmoidectomy) has been reported. The aim of this retrospective study is to evaluate the results of nonoperative management of emergency patients presenting with AD and EDA.
METHODS: The outcomes of 39 consecutive hemodynamically stable patients (23 men, mean age = 54.7 years) who were admitted with AD and EDA and were managed nonoperatively (antibiotic and supportive treatment) at a tertiary-care university hospital between January 2001 and June 2010 were retrospectively collected and analyzed. These included morbidity (Clavien-Dindo) and treatment failure (need for emergency surgery or death). A univariate analysis of clinical, radiological, and laboratory criteria with respect to treatment failure was performed. Results of delayed elective laparoscopic sigmoidectomy were also analyzed.
RESULTS: There was no mortality. Thirty-six of the 39 patients (92.3%) did not need surgery (7 patients required CT-guided abscess drainage). Mean hospital stay was 8.1 days. Duration of symptoms, previous antibiotic administration, severe sepsis, PCR level, WBC concentration, and the presence of abdominal collection were associated with treatment failure, whereas "distant" location of EDA and free abdominal fluid were not. Five patients had recurrence of AD and were treated medically. Seventeen patients (47.2%) underwent elective laparoscopic sigmoidectomy for which mean operative time was 246 min (range = 100-450) and the conversion rate was 11.8%. Mortality was nil and the morbidity rate was 41.2%. Mean postoperative stay was 7.1 days (range = 4-23).
CONCLUSIONS: Nonoperative management is a viable option in most emergency patients presenting with AD and EDA, even in the presence of symptoms of peritonitis or altered laboratory tests. Delayed laparoscopic sigmoidectomy may be useless in certain cases and its results poorer than expected.

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Year:  2012        PMID: 22274929     DOI: 10.1007/s00464-012-2157-z

Source DB:  PubMed          Journal:  Surg Endosc        ISSN: 0930-2794            Impact factor:   4.584


  36 in total

Review 1.  Clinical practice. Diverticulitis.

Authors:  Danny O Jacobs
Journal:  N Engl J Med       Date:  2007-11-15       Impact factor: 91.245

2.  Perforated diverticulitis managed by laparoscopic lavage.

Authors:  Craig J Taylor; Laurent Layani; Michael A Ghusn; Stephen I White
Journal:  ANZ J Surg       Date:  2006-11       Impact factor: 1.872

3.  Complicated diverticulitis: is it time to rethink the rules?

Authors:  Jennifer Chapman; Michael Davies; Bruce Wolff; Eric Dozois; Deron Tessier; Jeffrey Harrington; Dirk Larson
Journal:  Ann Surg       Date:  2005-10       Impact factor: 12.969

4.  Prognostic scoring systems to predict outcome in peritonitis and intra-abdominal sepsis.

Authors:  K Bosscha; K Reijnders; P F Hulstaert; A Algra; C van der Werken
Journal:  Br J Surg       Date:  1997-11       Impact factor: 6.939

5.  National hospital discharge survey: 2004 annual summary with detailed diagnosis and procedure data.

Authors:  Lola Jean Kozak; Carol Jean DeFrances; Margaret Jean Hall
Journal:  Vital Health Stat 13       Date:  2006-10

6.  Laparoscopic peritoneal lavage for generalized peritonitis due to perforated diverticulitis.

Authors:  E Myers; M Hurley; G C O'Sullivan; D Kavanagh; I Wilson; D C Winter
Journal:  Br J Surg       Date:  2008-01       Impact factor: 6.939

7.  Laparoscopic peritoneal lavage or primary anastomosis with defunctioning stoma for Hinchey 3 complicated diverticulitis: results of a comparative study.

Authors:  Mehdi Karoui; Axèle Champault; Karine Pautrat; Patrice Valleur; Daniel Cherqui; Gérard Champault
Journal:  Dis Colon Rectum       Date:  2009-04       Impact factor: 4.585

8.  Impact of CT-guided drainage in the treatment of diverticular abscesses: size matters.

Authors:  Bettina Siewert; Grace Tye; Jonathan Kruskal; Jacob Sosna; Frank Opelka; Vassilios Raptopoulos; S Nahum Goldberg
Journal:  AJR Am J Roentgenol       Date:  2006-03       Impact factor: 3.959

9.  Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.

Authors:  G C O'Sullivan; D Murphy; M G O'Brien; A Ireland
Journal:  Am J Surg       Date:  1996-04       Impact factor: 2.565

10.  Impact of primary resection on the outcome of patients with perforated diverticulitis.

Authors:  Vidhan Chandra; Heidi Nelson; Dirk Russell Larson; Jeffrey Robert Harrington
Journal:  Arch Surg       Date:  2004-11
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  27 in total

1.  CT imaging for prediction of complications and recurrence in acute uncomplicated diverticulitis.

Authors:  A Thorisson; K Smedh; M R Torkzad; L Påhlman; A Chabok
Journal:  Int J Colorectal Dis       Date:  2015-10-21       Impact factor: 2.571

2.  Operative or nonoperative management of Hinchey III purulent acute diverticulitis?

Authors:  Renato Costi; Alban Zarzavadjian le Bian; Claude Smadja; Vincenzo Violi
Journal:  Can J Surg       Date:  2016-02       Impact factor: 2.089

3.  Uncomplicated Acute Diverticulitis: Identifying Risk Factors for Severe Outcomes.

Authors:  Rebekah Jaung; Malsha Kularatna; Jason P Robertson; Ryash Vather; David Rowbotham; Andrew D MacCormick; Ian P Bissett
Journal:  World J Surg       Date:  2017-09       Impact factor: 3.352

4.  Nonoperative management of perforated acute diverticulitis with extraluminal air: results and risk factors of failure.

Authors:  Alberto Titos-García; Jose M Aranda-Narváez; Laura Romacho-López; Antonio J González-Sánchez; Isaac Cabrera-Serna; Julio Santoyo-Santoyo
Journal:  Int J Colorectal Dis       Date:  2017-07-17       Impact factor: 2.571

Review 5.  Current Options for the Emergency Management of Diverticular Disease and Options to Reduce the Need for Colostomy.

Authors:  Dimitra Theodoropoulos
Journal:  Clin Colon Rectal Surg       Date:  2018-06-22

6.  Perforated diverticulitis in the North of England: trends in patient outcomes, management approach and the influence of subspecialisation.

Authors:  T E Baldock; L R Brown; R C McLean
Journal:  Ann R Coll Surg Engl       Date:  2019-06-03       Impact factor: 1.891

7.  Factors Associated with Emergency Department Utilization and Admission in Patients with Colorectal Cancer.

Authors:  Tiffany K Weidner; John T Kidwell; David A Etzioni; Lindsey R Sangaralingham; Holly K Van Houten; Dennis Asante; Molly Moore Jeffery; Nilay Shah; Nabil Wasif
Journal:  J Gastrointest Surg       Date:  2018-02-12       Impact factor: 3.452

Review 8.  Diverticular disease: changing epidemiology and management.

Authors:  Roshan Razik; Geoffrey C Nguyen
Journal:  Drugs Aging       Date:  2015-05       Impact factor: 3.923

9.  Elective operation after acute complicated diverticulitis: is it still mandatory?

Authors:  Valérie Bridoux; Marlène Antor; Lilian Schwarz; Julien Cahais; Haitham Khalil; Francis Michot; Jean-Jacques Tuech
Journal:  World J Gastroenterol       Date:  2014-07-07       Impact factor: 5.742

10.  Validation of a grading system for complicated diverticulitis in the prediction of need for operative or percutaneous intervention.

Authors:  A K Y Fung; H Ahmeidat; D McAteer; E H Aly
Journal:  Ann R Coll Surg Engl       Date:  2015-04       Impact factor: 1.891

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