Literature DB >> 22271667

Identification of hydrophobic tags for the degradation of stabilized proteins.

Hyun Seop Tae1, Thomas B Sundberg, Taavi K Neklesa, Devin J Noblin, Jeffrey L Gustafson, Anke G Roth, Kanak Raina, Craig M Crews.   

Abstract

New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22271667      PMCID： PMC3338156          DOI： 10.1002/cbic.201100793

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  24 in total

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10.  Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

Authors:  Taavi K Neklesa; Hyun Seop Tae; Ashley R Schneekloth; Michael J Stulberg; Timothy W Corson; Thomas B Sundberg; Kanak Raina; Scott A Holley; Craig M Crews
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  29 in total

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9.  Development of small molecules targeting the pseudokinase Her3.

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10.  Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.

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