Literature DB >> 22271582

Cancer patients' fears related to clinical trial participation: a qualitative study.

Gwendolyn P Quinn1, Alexis Koskan, Kristen J Wells, Luis E Gonzalez, Cathy D Meade, Christie L Pratt Pozo, Paul B Jacobsen.   

Abstract

Patient-related barriers have hindered cancer patients' abilities to participate in the decision-making processes to participate in clinical trials. However, little is known about patients' emotional barrier of fear and how physicians influence this barrier. We conducted 48 in-depth interviews with cancer patients to determine their knowledge and attitudes about participating in clinical trials, transcribed interviews verbatim, and qualitatively analyzed the transcripts using content analysis. For the purpose of this manuscript, we focused on findings related to the role of the emotional barrier of fear in cancer patients' perceptions of participating in clinical trials. The majority of cancer patients (n = 40, 83.3%) discussed fears surrounding clinical trials, particularly as it related to cancer diagnosis, clinical trial participation, and fear of the unknown. In conclusion, providers might consider addressing the role of fear in patients' considering participating in a clinical trial.

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Mesh：

Year:  2012        PMID： 22271582      PMCID： PMC4095872          DOI： 10.1007/s13187-012-0310-y

Source DB:  PubMed          Journal:  J Cancer Educ        ISSN： 0885-8195            Impact factor:   2.037


  23 in total

Review 1.  Dilemmas in patient centeredness and shared decision making: a case for vulnerability.

Authors:  Hanneke de Haes
Journal:  Patient Educ Couns       Date:  2006-07-21

2.  Biased cognitive processing of cancer-related information among women with family histories of breast cancer: evidence from a cancer stroop task.

Authors:  Joel Erblich; Guy H Montgomery; Heiddis B Valdimarsdottir; Marylene Cloitre; Dana H Bovbjerg
Journal:  Health Psychol       Date:  2003-05       Impact factor: 4.267

3.  Cancer patients' information needs and information seeking behaviour: in depth interview study.

Authors:  G M Leydon; M Boulton; C Moynihan; A Jones; J Mossman; M Boudioni; K McPherson
Journal:  BMJ       Date:  2000-04-01

4.  Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment.

Authors:  P N Lara; R Higdon; N Lim; K Kwan; M Tanaka; D H Lau; T Wun; J Welborn; F J Meyers; S Christensen; R O'Donnell; C Richman; S A Scudder; J Tuscano; D R Gandara; K S Lam
Journal:  J Clin Oncol       Date:  2001-03-15       Impact factor: 44.544

5.  Participation in treatment decision-making by women with early stage breast cancer.

Authors:  Patricia Kenny; Susan Quine; Alan Shiell; Sue Cameron
Journal:  Health Expect       Date:  1999-09       Impact factor: 3.377

6.  Barriers to clinical trial participation as perceived by oncologists and patients.

Authors:  Neal J Meropol; Joanne S Buzaglo; Jennifer Millard; Nevena Damjanov; Suzanne M Miller; Caroline Ridgway; Eric A Ross; John D Sprandio; Perry Watts
Journal:  J Natl Compr Canc Netw       Date:  2007-09       Impact factor: 11.908

7.  Assessing oral literacy demand in genetic counseling dialogue: preliminary test of a conceptual framework.

Authors:  Debra L Roter; Lori H Erby; Susan Larson; Lee Ellington
Journal:  Soc Sci Med       Date:  2007-07-05       Impact factor: 4.634

Review 8.  A typology of shared decision making, informed consent, and simple consent.

Authors:  Simon N Whitney; Amy L McGuire; Laurence B McCullough
Journal:  Ann Intern Med       Date:  2004-01-06       Impact factor: 25.391

Review 9.  The impact of the intensity of fear on patient's delay regarding health care seeking behavior: a systematic review.

Authors:  Tatiana Dubayova; Jitse P van Dijk; Iveta Nagyova; Jaroslav Rosenberger; Eva Havlikova; Zuzana Gdovinova; Berrie Middel; Johan W Groothoff
Journal:  Int J Public Health       Date:  2010-05-14       Impact factor: 3.380

10.  What are the essential elements to enable patient participation in medical decision making?

Authors:  Liana Fraenkel; Sarah McGraw
Journal:  J Gen Intern Med       Date:  2007-05       Impact factor: 5.128
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  16 in total

1.  Barriers to study enrollment in patients with advanced cancer referred to a phase I clinical trials unit.

Authors:  Siqing Fu; Lacey McQuinn; Aung Naing; Jennifer J Wheler; Filip Janku; Gerald S Falchook; Sarina A Piha-Paul; Dennis Tu; Adrienne Howard; Apostolia Tsimberidou; Ralph Zinner; David S Hong; Razelle Kurzrock
Journal:  Oncologist       Date:  2013-10-23

2.  Patient Experience in Clinical Trials: Quality of Life, Financial Burden, and Perception of Care in Patients With Multiple Myeloma or Lymphoma Enrolled on Clinical Trials Compared With Standard Care.

Authors:  Surbhi Sidana; Cristine Allmer; Melissa C Larson; Amylou Dueck; Kathleen Yost; Rahma Warsame; Gita Thanarajasingam; James R Cerhan; Jonas Paludo; S Vincent Rajkumar; Thomas M Habermann; Grzegorz S Nowakowski; Yi Lin; Morie A Gertz; Thomas Witzig; Angela Dispenzieri; Wilson I Gonsalves; Stephen M Ansell; Carrie A Thompson; Shaji K Kumar
Journal:  JCO Oncol Pract       Date:  2022-05-17

3.  Patient and family member perspectives on searching for cancer clinical trials: A qualitative interview study.

Authors:  Jennifer L Ridgeway; Gladys B Asiedu; Katherine Carroll; Meaghan Tenney; Aminah Jatoi; Carmen Radecki Breitkopf
Journal:  Patient Educ Couns       Date:  2016-08-22

4.  Attitudinal barriers to participation in oncology clinical trials: factor analysis and correlates of barriers.

Authors:  S Manne; D Kashy; T Albrecht; Y-N Wong; A Lederman Flamm; A B Benson; S M Miller; Linda Fleisher; J Buzaglo; N Roach; M Katz; E Ross; M Collins; D Poole; S Raivitch; D M Miller; T G Kinzy; T Liu; N J Meropol
Journal:  Eur J Cancer Care (Engl)       Date:  2014-01-28       Impact factor: 2.520

5.  The bottleneck effect in lung cancer clinical trials.

Authors:  Luis E Gonzalez; Steven K Sutton; Christie Pratt; Matthew Gilbertson; Scott Antonia; Gwendolyn P Quinn
Journal:  J Cancer Educ       Date:  2013-09       Impact factor: 2.037

6.  Knowledge, attitudes, and self-efficacy as predictors of preparedness for oncology clinical trials: a mediational model.

Authors:  Sharon Manne; Deborah Kashy; Terrance Albrecht; Yu-Ning Wong; Anne Lederman Flamm; Al B Benson; Suzanne M Miller; Linda Fleisher; Joanne Buzaglo; Nancy Roach; Michael Katz; Eric Ross; Michael Collins; David Poole; Stephanie Raivitch; Dawn M Miller; Tyler G Kinzy; Tasnuva Liu; Neal J Meropol
Journal:  Med Decis Making       Date:  2013-11-18       Impact factor: 2.583

7.  Understanding Willingness to Participate in Cancer Clinical Trials Among Patients and Caregivers Attending a Minority-Serving Academic Cancer Center.

Authors:  Tamar Ginossar; Claudia Diaz Fuentes; John Oetzel
Journal:  J Cancer Educ       Date:  2022-02       Impact factor: 2.037

8.  Organizational development trajectory of a large academic radiotherapy department set up similarly to a prospective clinical trial: the MAASTRO experience.

Authors:  M Jacobs; L Boersma; A Dekker; E Hermanns; R Houben; M Govers; F van Merode; P Lambin
Journal:  Br J Radiol       Date:  2015-02-13       Impact factor: 3.039

9.  Perceptions and attitudes toward clinical trials in adolescent and young adults with cancer: a systematic review.

Authors:  Victoria Forcina; Branavan Vakeesan; Chelsea Paulo; Laura Mitchell; Jennifer Ah Bell; Seline Tam; Kate Wang; Abha A Gupta; Jeremy Lewin
Journal:  Adolesc Health Med Ther       Date:  2018-06-13

Review 10.  The role of emotions in cancer patients' decision-making.

Authors:  Ketti Mazzocco; Marianna Masiero; Maria Chiara Carriero; Gabriella Pravettoni
Journal:  Ecancermedicalscience       Date:  2019-03-28
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