BACKGROUND: To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy. METHODS: Each "pathologic" LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment. RESULTS: Seventy-nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p = .009). Also, this grouping predicts the response at the end of treatment. CONCLUSION: HPV-related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning.
BACKGROUND: To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy. METHODS: Each "pathologic" LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment. RESULTS: Seventy-nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p = .009). Also, this grouping predicts the response at the end of treatment. CONCLUSION:HPV-related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning.
Authors: Sandro V Porceddu; David I Pryor; Elizabeth Burmeister; Bryan H Burmeister; Michael G Poulsen; Matthew C Foote; Benedict Panizza; Scott Coman; David McFarlane; William Coman Journal: Head Neck Date: 2011-01-14 Impact factor: 3.147
Authors: Phillip K Pellitteri; Alfio Ferlito; Alessandra Rinaldo; Jatin P Shah; Randal S Weber; John Lowry; Jesus E Medina; Christine G Gourin; K Thomas Robbins; Carlos Suárez; Ashok R Shaha; Eric M Genden; C René Leemans; Jean Louis Lefebvre; Luiz P Kowalski; William I Wei Journal: Head Neck Date: 2006-02 Impact factor: 3.147
Authors: Eric K Hansen; M Kara Bucci; Jeanne M Quivey; Vivian Weinberg; Ping Xia Journal: Int J Radiat Oncol Biol Phys Date: 2005-10-26 Impact factor: 7.038
Authors: J P Bataini; J Bernier; B Asselain; C Lave; C Jaulerry; F Brunin; D Pontvert Journal: Int J Radiat Oncol Biol Phys Date: 1988-04 Impact factor: 7.038
Authors: Hiroya Ojiri; William M Mendenhall; Scott P Stringer; Patches L Johnson; Anthony A Mancuso Journal: Int J Radiat Oncol Biol Phys Date: 2002-02-01 Impact factor: 7.038
Authors: J N Munck; E Cvitkovic; J D Piekarski; E Benhamou; G Recondo; M Bachouchi; E Tellez-Bernal; B Luboinski; F Eschwege; P Wibault Journal: J Natl Cancer Inst Date: 1991-04-17 Impact factor: 13.506
Authors: Andrew R Gordon; Laurie A Loevner; Amita Shukla-Dave; Regina O Redfern; Adina I Sonners; Alex M Kilger; Mark A Elliott; Mitchell Machtay; Randal S Weber; Jerry D Glickson; David I Rosenthal Journal: AJNR Am J Neuroradiol Date: 2004 Jun-Jul Impact factor: 3.825
Authors: Jerry L Barker; Adam S Garden; K Kian Ang; Jennifer C O'Daniel; He Wang; Laurence E Court; William H Morrison; David I Rosenthal; K S Clifford Chao; Susan L Tucker; Radhe Mohan; Lei Dong Journal: Int J Radiat Oncol Biol Phys Date: 2004-07-15 Impact factor: 7.038
Authors: Mehdi Taghipour; Esther Mena; Matthew J Kruse; Sara Sheikhbahaei; Rathan M Subramaniam Journal: Nucl Med Commun Date: 2017-03 Impact factor: 1.690
Authors: Chad Tang; Clifton D Fuller; Adam S Garden; Musaddiq J Awan; Rivka R Colen; William H Morrison; Steven J Frank; Beth M Beadle; Jack Phan; Erich M Sturgis; Mark E Zafereo; Randal S Weber; David I Rosenthal; G Brandon Gunn Journal: Oral Oncol Date: 2014-11-28 Impact factor: 5.337
Authors: Adam S Garden; Gary B Gunn; Amy Hessel; Beth M Beadle; Salmaan Ahmed; Adel K El-Naggar; Clifton D Fuller; Lauren A Byers; Jack Phan; Steven J Frank; William H Morrison; Merill S Kies; David I Rosenthal; Erich M Sturgis Journal: Cancer Date: 2014-06-04 Impact factor: 6.860
Authors: P Boscolo-Rizzo; A Del Mistro; F Bussu; V Lupato; L Baboci; G Almadori; M C DA Mosto; G Paludetti Journal: Acta Otorhinolaryngol Ital Date: 2013-04 Impact factor: 2.124
Authors: Oliver J Gurney-Champion; Jennifer P Kieselmann; Kee H Wong; Brian Ng-Cheng-Hin; Kevin Harrington; Uwe Oelfke Journal: Phys Imaging Radiat Oncol Date: 2020-07
Authors: Whitney Sumner; Sangwoo S Kim; Lucas Vitzthum; Kevin Moore; Todd Atwood; James Murphy; Sayuri Miyauchi; Joseph A Califano; Loren K Mell; Arno J Mundt; Andrew B Sharabi Journal: Radiat Oncol Date: 2021-08-09 Impact factor: 3.481