Ping Liu1, Yu-Lei Sun, Jie Du, Xiao-Sai Hou, Hua Meng. 1. Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Inner Mongolia Medical College, Baotou, Inner Mongolia, China.
Abstract
AIM: To analyze the expression patterns of CD105 and Ki67 in human epithelial ovarian cancer (EOC) and to evaluate the clinical significance of these two markers in the progression and prognosis in EOC. MATERIALS AND METHODS: The CD105 and Ki67 protein expression patterns in paraffin-embedded specimens gathered from 166 patients with EOC were detected by immunohistochemistry analysis. The association of CD105 and Ki67 protein expression with the prognosis in EOC was subsequently assessed. RESULTS: The CD105 and Ki67 proteins were positively expressed in 101/166 (60.8%) and 129/166 (77.7%) of EOC patients, respectively. The CD105 tumors are more likely to have higher tumor grade (P = 0.02). Patients with positive Ki67 staining are more likely to be at the advanced stage of the disease (P = 0.008). Marker CD105 was positively correlated with Ki67 (r = 0.66, P = 0.01). In addition, Ki67 (hazards ratio [HR], 4.8; confidence interval [CI], 1.2-16.6; P = 0.008) and CD105⁺ (HR, 4.1; CI, 1.0-15.2; P = 0.01) were both independent prognostic factors for poor overall survival in EOC patients. Furthermore, combined CD105/Ki67 expression was significantly related to unfavorable overall survival (HR, 16.6; CI, 1.2-128.9; P < 0.001). CONCLUSIONS: Our results suggest that the CD105 and Ki67 expressions might be involved in the progression of EOC and patient prognosis. A combined detection of CD105/Ki67 coexpression may benefit us in predicting the prognosis in EOC.
AIM: To analyze the expression patterns of CD105 and Ki67 in humanepithelial ovarian cancer (EOC) and to evaluate the clinical significance of these two markers in the progression and prognosis in EOC. MATERIALS AND METHODS: The CD105 and Ki67 protein expression patterns in paraffin-embedded specimens gathered from 166 patients with EOC were detected by immunohistochemistry analysis. The association of CD105 and Ki67 protein expression with the prognosis in EOC was subsequently assessed. RESULTS: The CD105 and Ki67 proteins were positively expressed in 101/166 (60.8%) and 129/166 (77.7%) of EOC patients, respectively. The CD105 tumors are more likely to have higher tumor grade (P = 0.02). Patients with positive Ki67 staining are more likely to be at the advanced stage of the disease (P = 0.008). Marker CD105 was positively correlated with Ki67 (r = 0.66, P = 0.01). In addition, Ki67 (hazards ratio [HR], 4.8; confidence interval [CI], 1.2-16.6; P = 0.008) and CD105⁺ (HR, 4.1; CI, 1.0-15.2; P = 0.01) were both independent prognostic factors for poor overall survival in EOC patients. Furthermore, combined CD105/Ki67 expression was significantly related to unfavorable overall survival (HR, 16.6; CI, 1.2-128.9; P < 0.001). CONCLUSIONS: Our results suggest that the CD105 and Ki67 expressions might be involved in the progression of EOC and patient prognosis. A combined detection of CD105/Ki67 coexpression may benefit us in predicting the prognosis in EOC.
Authors: Anna Bachmayr-Heyda; Stefanie Aust; Georg Heinze; Stephan Polterauer; Christoph Grimm; Elena Ioana Braicu; Jalid Sehouli; Sandrina Lambrechts; Ignace Vergote; Sven Mahner; Dietmar Pils; Eva Schuster; Theresia Thalhammer; Reinhard Horvat; Carsten Denkert; Robert Zeillinger; Dan Cacsire Castillo-Tong Journal: BMC Cancer Date: 2013-09-17 Impact factor: 4.430
Authors: Brittany Anne Davidson; Jennifer M Rubatt; David L Corcoran; Deanna K Teoh; Marcus Q Bernardini; Lisa A Grace; William John Soper; Andrew Berchuck; Sharareh Siamakpour-Reihani; Wei Chen; Kouros Owzar; Susan K Murphy; Angeles Alvarez Secord Journal: Front Oncol Date: 2014-06-20 Impact factor: 6.244