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Literature DB >> 22258608

The promise of induced pluripotent stem cells in research and therapy.

Abstract

The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modelling human diseases and offers hope for personalized regenerative cell therapies. While the field is racing ahead, some researchers are pausing to evaluate whether induced pluripotent stem cells are indeed the true equivalents of embryonic stem cells and whether subtle differences between these types of cell might affect their research applications and therapeutic potential.

Entities: Chemical

Mesh：

Year: 2012 PMID： 22258608 PMCID： PMC3652331 DOI： 10.1038/nature10761

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

99 in total

1. Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells.

Authors: Bryce W Carey; Styliani Markoulaki; Jacob H Hanna; Dina A Faddah; Yosef Buganim; Jongpil Kim; Kibibi Ganz; Eveline J Steine; John P Cassady; Menno P Creyghton; G Grant Welstead; Qing Gao; Rudolf Jaenisch
Journal: Cell Stem Cell Date: 2011-12-02 Impact factor: 24.633

2. Lab-specific gene expression signatures in pluripotent stem cells.

Authors: Aaron M Newman; James B Cooper
Journal: Cell Stem Cell Date: 2010-08-06 Impact factor: 24.633

3. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

Authors: Yuki Ohi; Han Qin; Chibo Hong; Laure Blouin; Jose M Polo; Tingxia Guo; Zhongxia Qi; Sara L Downey; Philip D Manos; Derrick J Rossi; Jingwei Yu; Matthias Hebrok; Konrad Hochedlinger; Joseph F Costello; Jun S Song; Miguel Ramalho-Santos
Journal: Nat Cell Biol Date: 2011-04-17 Impact factor: 28.824

4. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.

Authors: Yin Shen; Youko Matsuno; Shaun D Fouse; Nagesh Rao; Sierra Root; Renhe Xu; Matteo Pellegrini; Arthur D Riggs; Guoping Fan
Journal: Proc Natl Acad Sci U S A Date: 2008-03-13 Impact factor: 11.205

5. Telomere dynamics in dyskeratosis congenita: the long and the short of iPS.

Authors: Suneet Agarwal; George Q Daley
Journal: Cell Res Date: 2011-07-26 Impact factor: 25.617

6. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.

Authors: Marius Wernig; Christopher J Lengner; Jacob Hanna; Michael A Lodato; Eveline Steine; Ruth Foreman; Judith Staerk; Styliani Markoulaki; Rudolf Jaenisch
Journal: Nat Biotechnol Date: 2008-07-01 Impact factor: 54.908

7. Reprogramming of pancreatic beta cells into induced pluripotent stem cells.

Authors: Matthias Stadtfeld; Kristen Brennand; Konrad Hochedlinger
Journal: Curr Biol Date: 2008-05-22 Impact factor: 10.834

8. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.

Authors: Suneet Agarwal; Yuin-Han Loh; Erin M McLoughlin; Junjiu Huang; In-Hyun Park; Justine D Miller; Hongguang Huo; Maja Okuka; Rosana Maria Dos Reis; Sabine Loewer; Huck-Hui Ng; David L Keefe; Frederick D Goldman; Aloysius J Klingelhutz; Lin Liu; George Q Daley
Journal: Nature Date: 2010-02-17 Impact factor: 49.962

9. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Authors: Luis F Z Batista; Matthew F Pech; Franklin L Zhong; Ha Nam Nguyen; Kathleen T Xie; Arthur J Zaug; Sharon M Crary; Jinkuk Choi; Vittorio Sebastiano; Athena Cherry; Neelam Giri; Marius Wernig; Blanche P Alter; Thomas R Cech; Sharon A Savage; Renee A Reijo Pera; Steven E Artandi
Journal: Nature Date: 2011-05-22 Impact factor: 49.962

10. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.

Authors: Knut Woltjen; Iacovos P Michael; Paria Mohseni; Ridham Desai; Maria Mileikovsky; Riikka Hämäläinen; Rebecca Cowling; Wei Wang; Pentao Liu; Marina Gertsenstein; Keisuke Kaji; Hoon-Ki Sung; Andras Nagy
Journal: Nature Date: 2009-03-01 Impact factor: 49.962

416 in total

1. Reprogramming in suspension.

Authors: Jiekai Chen; Duanqing Pei
Journal: Nat Methods Date: 2012-04-27 Impact factor: 28.547

Review 2. Optimizing cardiac repair and regeneration through activation of the endogenous cardiac stem cell compartment.

Authors: Georgina M Ellison; Bernardo Nadal-Ginard; Daniele Torella
Journal: J Cardiovasc Transl Res Date: 2012-06-12 Impact factor: 4.132

3. Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells.

Authors: Tea Soon Park; Ludovic Zimmerlin; Elias T Zambidis
Journal: Cytometry A Date: 2012-06-26 Impact factor: 4.355

4. Created equal? The many facets of cell reprogramming.

Authors: Annarosa Leri; Jan Kajstura
Journal: Circ Res Date: 2012-07-06 Impact factor: 17.367

5. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.

Authors: Daniel Paull; Ana Sevilla; Hongyan Zhou; Aana Kim Hahn; Hesed Kim; Christopher Napolitano; Alexander Tsankov; Linshan Shang; Katie Krumholz; Premlatha Jagadeesan; Chris M Woodard; Bruce Sun; Thierry Vilboux; Matthew Zimmer; Eliana Forero; Dorota N Moroziewicz; Hector Martinez; May Christine V Malicdan; Keren A Weiss; Lauren B Vensand; Carmen R Dusenberry; Hannah Polus; Karla Therese L Sy; David J Kahler; William A Gahl; Susan L Solomon; Stephen Chang; Alexander Meissner; Kevin Eggan; Scott A Noggle
Journal: Nat Methods Date: 2015-08-03 Impact factor: 28.547

6. Advances in Applications of Metabolomics in Pluripotent Stem Cell Research.

Authors: Vijesh J Bhute; Xiaoping Bao; Sean P Palecek
Journal: Curr Opin Chem Eng Date: 2016-12-15 Impact factor: 5.163

Review 7. Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs.

Authors: Chao-Shun Yang; Tariq M Rana
Journal: Mol Biosyst Date: 2012-10-05

Review 8. Induced pluripotent stem cells: the new patient?

Authors: Milena Bellin; Maria C Marchetto; Fred H Gage; Christine L Mummery
Journal: Nat Rev Mol Cell Biol Date: 2012-10-04 Impact factor: 94.444

9. Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells.

Authors: Johannes Kuehle; Soeren Turan; Tobias Cantz; Dirk Hoffmann; Julia D Suerth; Tobias Maetzig; Daniela Zychlinski; Christoph Klein; Doris Steinemann; Christopher Baum; Juergen Bode; Axel Schambach
Journal: Mol Ther Date: 2014-01-17 Impact factor: 11.454

10. Characterization of embryonic stem-like cells derived from HEK293T cells through miR302/367 expression and their potentiality to differentiate into germ-like cells.

Authors: Long Wang; Haijing Zhu; Jiang Wu; Na Li; Jinlian Hua
Journal: Cytotechnology Date: 2013-10-05 Impact factor: 2.058