Literature DB >> 22252651

Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters.

Dhevalapally B Ramachary1, Chintalapudi Venkaiah, Patoju Murali Krishna.   

Abstract

We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22252651     DOI： 10.1039/c2cc17219d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products.

Authors:  Christina M Bock; Gangajji Parameshwarappa; Simon Bönisch; Walter Bauer; Corina Hutterer; Maria Leidenberger; Oliver Friedrich; Manfred Marschall; Barbara Kappes; Andreas Görling; Svetlana B Tsogoeva
Journal:  ChemistryOpen       Date:  2017-04-26       Impact factor: 2.911

2.  Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds.

Authors:  Takashi Yamazaki; Yoh Nakajima; Minato Iida; Tomoko Kawasaki-Takasuka
Journal:  Beilstein J Org Chem       Date:  2021-01-15       Impact factor: 2.883

3.  [3+2] regioselective annulation reaction of 2-arylidene-1,3-indandiones towards synthesis of spirocyclopentenes: understanding the mechanism of γ-attack vs. α-attack using DFT studies.

Authors:  Shaik Anwar; Li-Tzu Lin; V Srinivasadesikan; Veera Babu Gudise; Kwunmin Chen
Journal:  RSC Adv       Date:  2021-12-01       Impact factor: 4.036

4.  Streamlined asymmetric α-difunctionalization of ynones.

Authors:  Siyu Peng; Zhaofeng Wang; Linxing Zhang; Xinhao Zhang; Yong Huang
Journal:  Nat Commun       Date:  2018-01-25       Impact factor: 14.919
  4 in total

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