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Literature DB >> 33520000

Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds.

Takashi Yamazaki¹, Yoh Nakajima¹, Minato Iida¹, Tomoko Kawasaki-Takasuka¹.

Abstract

The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are reported.

Entities: Chemical

Keywords: CF3-containing propargylic alcohols; CF3-containing ynones; oxidation; pyrimidines; salicylate derivatives

Year: 2021 PMID： 33520000 PMCID： PMC7814177 DOI： 10.3762/bjoc.17.14

Source DB: PubMed Journal: Beilstein J Org Chem ISSN： 1860-5397 Impact factor: 2.883

16 in total

1. Borazine-CF₃^- Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation.

Authors: Jacob B Geri; Michael M Wade Wolfe; Nathaniel K Szymczak
Journal: Angew Chem Int Ed Engl Date: 2018-01-09 Impact factor: 15.336

2. Application of Mitsunobu reagents to redox isomerization of CF3-containing propargylic alcohols to (E)-α,β-enones.

Authors: Yohsuke Watanabe; Takashi Yamazaki
Journal: J Org Chem Date: 2011-02-23 Impact factor: 4.354

Review 3. Fluorine-Containing Drugs Approved by the FDA in 2018.

Authors: Haibo Mei; Jianlin Han; Santos Fustero; Mercedes Medio-Simon; Daniel M Sedgwick; Claudio Santi; Renzo Ruzziconi; Vadim A Soloshonok
Journal: Chemistry Date: 2019-07-08 Impact factor: 5.236

4. Electronically promoted Payne rearrangement of 3-CF3-2,3-epoxyalcohols.

Authors: Takashi Yamazaki; Tatsuro Ichige; Tomoya Kitazume
Journal: Org Lett Date: 2004-10-28 Impact factor: 6.005

5. Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters.

Authors: Dhevalapally B Ramachary; Chintalapudi Venkaiah; Patoju Murali Krishna
Journal: Chem Commun (Camb) Date: 2012-01-18 Impact factor: 6.222

6. Rhodium(i)-catalysed intermolecular alkyne insertion into (2-pyridylmethylene)cyclobutenes.

Authors: Takanori Matsuda; Takeshi Matsumoto
Journal: Org Biomol Chem Date: 2016-05-19 Impact factor: 3.876

Review 7. Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

Authors: Jiang Wang; María Sánchez-Roselló; José Luis Aceña; Carlos del Pozo; Alexander E Sorochinsky; Santos Fustero; Vadim A Soloshonok; Hong Liu
Journal: Chem Rev Date: 2013-12-03 Impact factor: 60.622