INTRODUCTION: This prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year. MATERIALS AND METHODS: From 3,811 consecutive CLBP patients referred to lumbar spine MRI 54 patients with a large M1 were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11-18 months. RESULTS: At baseline M1 was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable M1 was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without M1, progression of degenerative changes was rare. CONCLUSION: Endplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with M1.
INTRODUCTION: This prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year. MATERIALS AND METHODS: From 3,811 consecutive CLBP patients referred to lumbar spine MRI 54 patients with a large M1 were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11-18 months. RESULTS: At baseline M1 was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable M1 was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without M1, progression of degenerative changes was rare. CONCLUSION: Endplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with M1.
Authors: Norbert Boos; Sabine Weissbach; Helmut Rohrbach; Christoph Weiler; Kevin F Spratt; Andreas G Nerlich Journal: Spine (Phila Pa 1976) Date: 2002-12-01 Impact factor: 3.468
Authors: Tue Secher Jensen; Per Kjaer; Lars Korsholm; Tom Bendix; Joan S Sorensen; Claus Manniche; Charlotte Leboeuf-Yde Journal: Eur Spine J Date: 2009-11-18 Impact factor: 3.134
Authors: Fernando Ruiz Santiago; Antonio Jesús Láinez Ramos-Bossini; Yì Xiáng J Wáng; José Pablo Martínez Barbero; Jade García Espinosa; Alberto Martínez Martínez Journal: Quant Imaging Med Surg Date: 2022-07
Authors: Tobias A Mattei; Azeem A Rehman; Alisson R Teles; Jean C Aldag; Dzung H Dinh; Todd D McCall Journal: Neurosurg Rev Date: 2016-06-11 Impact factor: 3.042
Authors: Juhani H Määttä; Minna Kraatari; Lisa Wolber; Jaakko Niinimäki; Sam Wadge; Jaro Karppinen; Frances M K Williams Journal: Eur Spine J Date: 2014-05-15 Impact factor: 3.134