Literature DB >> 22247174

Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.

Lei Shao1, Jiachen Zi, Jia Zeng, Jixun Zhan.   

Abstract

The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.

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Year:  2012        PMID： 22247174      PMCID： PMC3298124          DOI： 10.1128/AEM.06904-11

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  24 in total

1.  Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.

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Journal:  DNA Seq       Date:  2004-04

2.  Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea.

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3.  A family of bacterial regulators homologous to Gal and Lac repressors.

Authors:  M J Weickert; S Adhya
Journal:  J Biol Chem       Date:  1992-08-05       Impact factor: 5.157

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Authors:  Yun Zhang; James S Panek
Journal:  Org Lett       Date:  2007-07-13       Impact factor: 6.005

5.  Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor.

Authors:  Y Koguchi; M Nishio; J Kotera; K Omori; T Ohnuki; S Komatsubara
Journal:  J Antibiot (Tokyo)       Date:  1997-11       Impact factor: 2.649

Review 6.  Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors.

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Journal:  FEBS Lett       Date:  1995-12-18       Impact factor: 4.124

7.  A chain initiation factor common to both modular and aromatic polyketide synthases.

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Journal:  Nature       Date:  1999-09-30       Impact factor: 49.962

8.  A tylosin ketoreductase reveals how chirality is determined in polyketides.

Authors:  Adrian T Keatinge-Clay
Journal:  Chem Biol       Date:  2007-08

9.  Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

Authors:  M Miller-Wideman; N Makkar; M Tran; B Isaac; N Biest; R Stonard
Journal:  J Antibiot (Tokyo)       Date:  1992-06       Impact factor: 2.649

10.  The RAST Server: rapid annotations using subsystems technology.

Authors:  Ramy K Aziz; Daniela Bartels; Aaron A Best; Matthew DeJongh; Terrence Disz; Robert A Edwards; Kevin Formsma; Svetlana Gerdes; Elizabeth M Glass; Michael Kubal; Folker Meyer; Gary J Olsen; Robert Olson; Andrei L Osterman; Ross A Overbeek; Leslie K McNeil; Daniel Paarmann; Tobias Paczian; Bruce Parrello; Gordon D Pusch; Claudia Reich; Rick Stevens; Olga Vassieva; Veronika Vonstein; Andreas Wilke; Olga Zagnitko
Journal:  BMC Genomics       Date:  2008-02-08       Impact factor: 3.969
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  9 in total

1.  RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

Authors:  Hideaki Kakeya; Daisuke Kaida; Hiromi Sekiya; Koji Nagai; Minoru Yoshida; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2015-09-09       Impact factor: 2.649

Review 2.  The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Authors:  Adrian T Keatinge-Clay
Journal:  Chem Rev       Date:  2017-04-10       Impact factor: 60.622

3.  An indigoidine biosynthetic gene cluster from Streptomyces chromofuscus ATCC 49982 contains an unusual IndB homologue.

Authors:  Dayu Yu; Fuchao Xu; Jonathan Valiente; Siyuan Wang; Jixun Zhan
Journal:  J Ind Microbiol Biotechnol       Date:  2012-10-10       Impact factor: 3.346

4.  Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.

Authors:  Alessandra S Eustáquio; Jeffrey E Janso; Anokha S Ratnayake; Christopher J O'Donnell; Frank E Koehn
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-05       Impact factor: 11.205

5.  Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.

Authors:  Drew T Wagner; Zhicheng Zhang; Roy A Meoded; Alexis J Cepeda; Jörn Piel; Adrian T Keatinge-Clay
Journal:  ACS Chem Biol       Date:  2018-03-01       Impact factor: 5.100

6.  GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts.

Authors:  Eve A Granatosky; Nina DiPrimio; Jarred R E Pickering; D Cole Stevens; Ethan O Perlstein; Richard E Taylor
Journal:  J Nat Prod       Date:  2018-09-06       Impact factor: 4.050

7.  Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus.

Authors:  Lei Sun; Jia Zeng; Peiwu Cui; Wei Wang; Dayu Yu; Jixun Zhan
Journal:  J Biol Eng       Date:  2018-06-07       Impact factor: 4.355

8.  Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli.

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Journal:  J Biol Eng       Date:  2019-03-21       Impact factor: 4.355

Review 9.  Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.

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  9 in total

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