PURPOSE: To evaluate the dependence of skeletal muscle blood oxygenation level-dependent (BOLD) effect and time course characteristics on magnetic field strength in healthy volunteers using an ischemia/reactive hyperemia paradigm. MATERIALS AND METHODS: Two consecutive skeletal muscle BOLD magnetic resonance imaging (MRI) measurements in eight healthy volunteers were performed on 1.5 T and 3.0 T whole-body MRI scanners. For both measurements a fat-saturated multi-shot multiecho gradient-echo EPI sequence was applied. Temporary vascular occlusion was induced by suprasystolic cuff compression of the thigh. T2 time courses were obtained from two different calf muscles and characterized by typical curve parameters. Ischemia- and hyperemia-induced changes in R2 (ΔR2) were calculated for both muscles in each volunteer at the two field strengths. RESULTS: Skeletal muscle BOLD changes are dependent on magnetic field strength as the ratio ΔR2(3.0 T)/ΔR2(1.5 T) was found to range between 1.6 and 2.2. Regarding time course characteristics, significantly higher relative T2 changes were found in both muscles at 3.0 T. CONCLUSION: The present study shows an approximately linear field strength dependence of ΔR2 in the skeletal muscle in response to ischemia and reactive hyperemia. Using higher magnetic fields is advisable for future BOLD imaging studies of peripheral limb pathologies.
PURPOSE: To evaluate the dependence of skeletal muscle blood oxygenation level-dependent (BOLD) effect and time course characteristics on magnetic field strength in healthy volunteers using an ischemia/reactive hyperemia paradigm. MATERIALS AND METHODS: Two consecutive skeletal muscle BOLD magnetic resonance imaging (MRI) measurements in eight healthy volunteers were performed on 1.5 T and 3.0 T whole-body MRI scanners. For both measurements a fat-saturated multi-shot multiecho gradient-echo EPI sequence was applied. Temporary vascular occlusion was induced by suprasystolic cuff compression of the thigh. T2 time courses were obtained from two different calf muscles and characterized by typical curve parameters. Ischemia- and hyperemia-induced changes in R2 (ΔR2) were calculated for both muscles in each volunteer at the two field strengths. RESULTS: Skeletal muscle BOLD changes are dependent on magnetic field strength as the ratio ΔR2(3.0 T)/ΔR2(1.5 T) was found to range between 1.6 and 2.2. Regarding time course characteristics, significantly higher relative T2 changes were found in both muscles at 3.0 T. CONCLUSION: The present study shows an approximately linear field strength dependence of ΔR2 in the skeletal muscle in response to ischemia and reactive hyperemia. Using higher magnetic fields is advisable for future BOLD imaging studies of peripheral limb pathologies.
Authors: Erin K Englund; Zachary B Rodgers; Michael C Langham; Emile R Mohler; Thomas F Floyd; Felix W Wehrli Journal: Magn Reson Med Date: 2017-05-11 Impact factor: 4.668
Authors: Sharif Kershah; Sasan Partovi; Bryan J Traughber; Raymond F Muzic; Mark D Schluchter; James K O'Donnell; Peter Faulhaber Journal: Mol Imaging Biol Date: 2013-12 Impact factor: 3.488
Authors: Erin K Englund; Michael C Langham; Cheng Li; Zachary B Rodgers; Thomas F Floyd; Emile R Mohler; Felix W Wehrli Journal: J Cardiovasc Magn Reson Date: 2013-08-19 Impact factor: 5.364
Authors: Sarah L West; Clodagh S O'Gorman; Alyaa H Elzibak; Jessica Caterini; Michael D Noseworthy; Tammy Rayner; Jill Hamilton; Greg D Wells Journal: BBA Clin Date: 2014-12-09