Erin K Englund1, Zachary B Rodgers1, Michael C Langham1, Emile R Mohler2, Thomas F Floyd3, Felix W Wehrli1. 1. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 2. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 3. Department of Anesthesiology, Stony Brook University, Stony Brook, New York, USA.
Abstract
PURPOSE: To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called "Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*" (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*, all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( V˙O2) via the Fick principle. METHODS: In five subjects, vPIVOT-derived results were compared with those obtained from stand-alone sequences during separate ischemia-reperfusion paradigms to investigate the presence of measurement bias. Subsequently, in 10 subjects, vPIVOT was applied to assess muscle hemodynamics and V˙O2 following a bout of dynamic plantar flexion contractions. RESULTS: From the ischemia-reperfusion paradigm, no significant differences were observed between data from vPIVOT and comparison sequences. After exercise, the macrovascular flow response reached a maximum 8 ± 3 s after relaxation; however, perfusion in the gastrocnemius muscle continued to rise for 101 ± 53 s. Peak V˙O2 calculated based on mass-normalized arterial blood flow or perfusion was 15.2 ± 6.7 mL O2 /min/100 g or 6.0 ± 1.9 mL O2 /min/100 g, respectively. CONCLUSIONS: vPIVOT is a new method to measure blood flow and oxygen saturation, and therefore to quantify muscle oxygen consumption. Magn Reson Med 79:846-855, 2018.
PURPOSE: To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called "Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*" (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*, all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( V˙O2) via the Fick principle. METHODS: In five subjects, vPIVOT-derived results were compared with those obtained from stand-alone sequences during separate ischemia-reperfusion paradigms to investigate the presence of measurement bias. Subsequently, in 10 subjects, vPIVOT was applied to assess muscle hemodynamics and V˙O2 following a bout of dynamic plantar flexion contractions. RESULTS: From the ischemia-reperfusion paradigm, no significant differences were observed between data from vPIVOT and comparison sequences. After exercise, the macrovascular flow response reached a maximum 8 ± 3 s after relaxation; however, perfusion in the gastrocnemius muscle continued to rise for 101 ± 53 s. Peak V˙O2 calculated based on mass-normalized arterial blood flow or perfusion was 15.2 ± 6.7 mL O2 /min/100 g or 6.0 ± 1.9 mL O2 /min/100 g, respectively. CONCLUSIONS:vPIVOT is a new method to measure blood flow and oxygen saturation, and therefore to quantify muscle oxygen consumption. Magn Reson Med 79:846-855, 2018.
Authors: Hans-Peter Ledermann; Anja-Carina Schulte; Hanns-Georg Heidecker; Markus Aschwanden; Kurt A Jäger; Klaus Scheffler; Wolfgang Steinbrich; Deniz Bilecen Journal: Circulation Date: 2006-06-19 Impact factor: 29.690
Authors: Zachary B Rodgers; Varsha Jain; Erin K Englund; Michael C Langham; Felix W Wehrli Journal: J Cereb Blood Flow Metab Date: 2013-07-10 Impact factor: 6.200
Authors: Wen-Chau Wu; Jiongjiong Wang; John A Detre; Sarah J Ratcliffe; Thomas F Floyd Journal: J Magn Reson Imaging Date: 2008-08 Impact factor: 4.813
Authors: Wen-Chau Wu; Emile Mohler; Sarah J Ratcliffe; Felix W Wehrli; John A Detre; Thomas F Floyd Journal: J Am Coll Cardiol Date: 2009-06-23 Impact factor: 24.094
Authors: Nicolas Decorte; Tania Buehler; Ericky Caldas de Almeida Araujo; Alexandre Vignaud; Pierre G Carlier Journal: J Vasc Res Date: 2014-12-12 Impact factor: 1.934
Authors: Erin K Englund; Michael C Langham; Felix W Wehrli; Molly J Fanning; Zeeshan Khan; Kathryn H Schmitz; Sarah J Ratcliffe; Thomas F Floyd; Emile R Mohler Journal: Am J Physiol Heart Circ Physiol Date: 2022-07-08 Impact factor: 5.125
Authors: Bryan Haddock; Sofie K Hansen; Ulrich Lindberg; Jakob Lindberg Nielsen; Ulrik Frandsen; Per Aagaard; Henrik B W Larsson; Charlotte Suetta Journal: J Appl Physiol (1985) Date: 2020-08-27
Authors: Jon Stavres; Christopher T Sica; Cheryl Blaha; Michael Herr; Jianli Wang; Samuel Pai; Aimee Cauffman; Jeffrey Vesek; Qing X Yang; Lawrence I Sinoway Journal: Physiol Rep Date: 2019-10
Authors: Ushnah S U Din; Tanvir S Sian; Colleen S Deane; Ken Smith; Amanda Gates; Jonathan N Lund; John P Williams; Ricardo Rueda; Suzette L Pereira; Philip J Atherton; Bethan E Phillips Journal: Nutrients Date: 2021-10-29 Impact factor: 6.706
Authors: Tanvir S Sian; Ushnah S U Din; Colleen S Deane; Ken Smith; Amanda Gates; Jonathan N Lund; John P Williams; Ricardo Rueda; Suzette L Pereira; Bethan E Phillips; Philip J Atherton Journal: Nutrients Date: 2021-05-13 Impact factor: 5.717
Authors: Colleen S Deane; Ushnah S U Din; Tanvir S Sian; Ken Smith; Amanda Gates; Jonathan N Lund; John P Williams; Ricardo Rueda; Suzette L Pereira; Philip J Atherton; Bethan E Phillips Journal: Nutrients Date: 2022-03-21 Impact factor: 6.706