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Literature DB >> 22222604

An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl₂-induced apoptosis.

Jie Men¹, Xiaohui Zhang, Yang Yang, Dianwen Gao.

Abstract

Some ocular diseases characterized by apoptotic death of retinal ganglion cells (RGCs) and Alzheimer's disease (AD) are chronic neurodegenerative disorders and have similarities in neuropathology. Humanin (HN) is known for its ability to suppress neuronal death induced by AD-related insults. In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells. Hypoxia mimetic compound cobalt chloride (CoCl₂) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects. This finding may provide new therapeutics for the retinal neurodegenerative diseases targeting neuroprotection.

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Year: 2012 PMID： 22222604 DOI： 10.1007/s12031-011-9701-5

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

29 in total

Review 1. Oxygen-dependent diseases in the retina: role of hypoxia-inducible factors.

Authors: Olli Arjamaa; Mikko Nikinmaa
Journal: Exp Eye Res Date: 2006-06-05 Impact factor: 3.467

2. Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.

Authors: Dimitra Benaki; Christos Zikos; Alexandra Evangelou; Evangelia Livaniou; Metaxia Vlassi; Emmanuel Mikros; Maria Pelecanou
Journal: Biochem Biophys Res Commun Date: 2005-04-01 Impact factor: 3.575

3. Vitreous fluid levels of beta-amyloid((1-42)) and tau in patients with retinal diseases.

Authors: Shinji Yoneda; Hideaki Hara; Akira Hirata; Mikiko Fukushima; Yasuya Inomata; Hidenobu Tanihara
Journal: Jpn J Ophthalmol Date: 2005 Mar-Apr Impact factor: 2.447

4. Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

Authors: Yuichi Hashimoto; Hiroaki Suzuki; Sadakazu Aiso; Takako Niikura; Ikuo Nishimoto; Masaaki Matsuoka
Journal: Life Sci Date: 2005-07-06 Impact factor: 5.037

5. High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease.

Authors: Hiroki Tamura; Hideshi Kawakami; Takashi Kanamoto; Tomoko Kato; Tomoko Yokoyama; Ken Sasaki; Yuishin Izumi; Masayasu Matsumoto; Hiromu K Mishima
Journal: J Neurol Sci Date: 2006-03-06 Impact factor: 3.181

6. Humanin inhibits cell death of serum-deprived PC12h cells.

Authors: Shingo Kariya; Nobuyuki Takahashi; Naoki Ooba; Makoto Kawahara; Hitoshi Nakayama; Satoshi Ueno
Journal: Neuroreport Date: 2002-05-07 Impact factor: 1.837

7. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.

Authors: Stuart J McKinnon; Donna M Lehman; Lisa A Kerrigan-Baumrind; Carol A Merges; Mary Ellen Pease; Danielle F Kerrigan; Nancy L Ransom; N Grace Tahzib; Herbert A Reitsamer; Hana Levkovitch-Verbin; Harry A Quigley; Donald J Zack
Journal: Invest Ophthalmol Vis Sci Date: 2002-04 Impact factor: 4.799

8. Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.

Authors: Gabriela Krejcova; Jiri Patocka; Jirina Slaninova
Journal: J Pept Sci Date: 2004-10 Impact factor: 1.905

9. Humanin peptide suppresses apoptosis by interfering with Bax activation.

Authors: Bin Guo; Dayong Zhai; Edelmira Cabezas; Kate Welsh; Shahrzad Nouraini; Arnold C Satterthwait; John C Reed
Journal: Nature Date: 2003-05-04 Impact factor: 49.962

10. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

Authors: Yuichi Hashimoto; Megumi Kurita; Sadakazu Aiso; Ikuo Nishimoto; Masaaki Matsuoka
Journal: Mol Biol Cell Date: 2009-04-22 Impact factor: 4.138

15 in total

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Journal: J Mol Endocrinol Date: 2013-01-11 Impact factor: 5.098

2. Murine maternal dietary restriction affects neural Humanin expression and cellular profile.

Authors: Claire Baldauf; Monica Sondhi; Bo-Chul Shin; Young Eun Ko; Xin Ye; Kuk-Wha Lee; Sherin U Devaskar
Journal: J Neurosci Res Date: 2019-12-15 Impact factor: 4.164

3. Inhibition of miR-134 Protects Against Hydrogen Peroxide-Induced Apoptosis in Retinal Ganglion Cells.

Authors: Yi Shao; Yao Yu; Qiong Zhou; Cheng Li; Lu Yang; Chong-Gang Pei
Journal: J Mol Neurosci Date: 2015-03-06 Impact factor: 3.444

Review 4. The retina as a window to the brain-from eye research to CNS disorders.

Authors: Anat London; Inbal Benhar; Michal Schwartz
Journal: Nat Rev Neurol Date: 2012-11-20 Impact factor: 42.937

Review 5. Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.

Authors: Masaaki Matsuoka
Journal: Mol Neurobiol Date: 2014-06-27 Impact factor: 5.590