Literature DB >> 24166353

Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo.

Yue Xu1, Shanshan Yu, Qinmeng Shu, Lu Yang, Cheng Yang, Jiawei Wang, Fan Xu, Min Ji, Xiaoling Liang.   

Abstract

Previous studies have shown activation of cyclic AMP response element-binding protein (CREB) family is involved in the retinal ganglion cells (RGCs) protection. However, the function of cyclic AMP response element modulator-1 (CREM-1), one member of the CREB family, is still with limited acquaintance. To investigate whether CREM-1 is involved in RGCs death, we performed a light-induced retinal damage model in adult rats. Upregulation of CREM-1 was observed in retina after light-induced damage by performing western blot. Immunofluorescent labeling indicated that upregulated CREM-1 was localized mainly in the RGCs. We also investigated co-localization of CREM-1 with active-caspase-3 and TUNEL (apoptotic markers) in the retina after light-induced damage. In addition, the expression patterns of B cell lymphoma/leukemia-2 and Bcl-2 associated X protein were parallel with that of CREM-1. Collectively, we hypothesized upregulation of CREM-1 in the retina was associated with RGCs death after light-induced damage.

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Year:  2013        PMID： 24166353     DOI： 10.1007/s12031-013-0153-y

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  49 in total

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  8 in total

1.  Up-Regulation of PKM2 Relates to Retinal Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats.

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2.  Expression of RBMX in the light-induced damage of rat retina in vivo.

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Review 5.  Caspases in retinal ganglion cell death and axon regeneration.

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6.  Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.

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7.  Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush.

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8.  Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.

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  8 in total

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