BACKGROUND: The association between the TERT rs2736100 single nucleotide polymorphism (SNP) and cancer risk has been studied by many researchers, but the results remain inconclusive. To further explore this association, we performed a meta-analysis. METHODS: A computerized search of PubMed and Embase database for publications on the TERT rs2736100 polymorphism and cancer risk was performed and the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis and assessment of bias were performed in our meta-analysis. RESULTS: A significant association between the TERT rs2736100 polymorphism and cancer susceptibility was revealed by the results of the meta-analysis of the 25 case-control studies (GG versus TT: OR = 1.72, 95% CI: 1.58, 1.88; GT versus TT: OR = 1.38, 95% CI: 1.29, 1.47; dominant model-TG + GG versus TT: OR = 1.47, 95% CI: 1.37, 1.58; recessive model-GG versus TT + TG: OR = 1.37, 95% CI 1.31, 1.43; additive model-2GG + TG versus 2TT + TG: OR = 1.30, 95% CI: 1.25, 1.36). Moreover, increased cancer risk in all genetic models was found after stratification of the SNP data by cancer type, ethnicity and source of controls. CONCLUSIONS: In all genetic models, the association between the TERT rs2736100 polymorphism and cancer risk was significant. This meta-analysis suggests that the TERT rs2736100 polymorphism may be a risk factor for cancer. Further functional studies between this polymorphism and cancer risk are warranted.
BACKGROUND: The association between the TERTrs2736100 single nucleotide polymorphism (SNP) and cancer risk has been studied by many researchers, but the results remain inconclusive. To further explore this association, we performed a meta-analysis. METHODS: A computerized search of PubMed and Embase database for publications on the TERTrs2736100 polymorphism and cancer risk was performed and the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis and assessment of bias were performed in our meta-analysis. RESULTS: A significant association between the TERTrs2736100 polymorphism and cancer susceptibility was revealed by the results of the meta-analysis of the 25 case-control studies (GG versus TT: OR = 1.72, 95% CI: 1.58, 1.88; GT versus TT: OR = 1.38, 95% CI: 1.29, 1.47; dominant model-TG + GG versus TT: OR = 1.47, 95% CI: 1.37, 1.58; recessive model-GG versus TT + TG: OR = 1.37, 95% CI 1.31, 1.43; additive model-2GG + TG versus 2TT + TG: OR = 1.30, 95% CI: 1.25, 1.36). Moreover, increased cancer risk in all genetic models was found after stratification of the SNP data by cancer type, ethnicity and source of controls. CONCLUSIONS: In all genetic models, the association between the TERTrs2736100 polymorphism and cancer risk was significant. This meta-analysis suggests that the TERTrs2736100 polymorphism may be a risk factor for cancer. Further functional studies between this polymorphism and cancer risk are warranted.
Authors: Luo Wang; Qingyi Wei; Li-E Wang; Kenneth D Aldape; Yumei Cao; M Fatih Okcu; Kenneth R Hess; Randa El-Zein; Mark R Gilbert; Shiao Y Woo; Sujit S Prabhu; Greg N Fuller; Melissa L Bondy Journal: J Clin Oncol Date: 2006-04-01 Impact factor: 44.544
Authors: Margaret R Spitz; Christopher I Amos; Susan Land; Xifeng Wu; Qiong Dong; Angela S Wenzlaff; Ann G Schwartz Journal: J Thorac Oncol Date: 2013-04 Impact factor: 15.609
Authors: Byung Joon Choi; Jung Hwan Yoon; Olga Kim; Won Suk Choi; Suk Woo Nam; Jung Young Lee; Won Sang Park Journal: World J Gastroenterol Date: 2015-08-21 Impact factor: 5.742
Authors: Jinyoung Byun; Younghun Han; Quinn T Ostrom; Jacob Edelson; Kyle M Walsh; Rowland W Pettit; Melissa L Bondy; Rayjean J Hung; James D McKay; Christopher I Amos Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-03-26 Impact factor: 4.090
Authors: Stig E Bojesen; Karen A Pooley; Sharon E Johnatty; Jonathan Beesley; Kyriaki Michailidou; Jonathan P Tyrer; Stacey L Edwards; Hilda A Pickett; Howard C Shen; Chanel E Smart; Kristine M Hillman; Phuong L Mai; Kate Lawrenson; Michael D Stutz; Yi Lu; Rod Karevan; Nicholas Woods; Rebecca L Johnston; Juliet D French; Xiaoqing Chen; Maren Weischer; Sune F Nielsen; Melanie J Maranian; Maya Ghoussaini; Shahana Ahmed; Caroline Baynes; Manjeet K Bolla; Qin Wang; Joe Dennis; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Sue Healey; Michael Lush; Daniel C Tessier; Daniel Vincent; Françis Bacot; Ignace Vergote; Sandrina Lambrechts; Evelyn Despierre; Harvey A Risch; Anna González-Neira; Mary Anne Rossing; Guillermo Pita; Jennifer A Doherty; Nuria Alvarez; Melissa C Larson; Brooke L Fridley; Nils Schoof; Jenny Chang-Claude; Mine S Cicek; Julian Peto; Kimberly R Kalli; Annegien Broeks; Sebastian M Armasu; Marjanka K Schmidt; Linde M Braaf; Boris Winterhoff; Heli Nevanlinna; Gottfried E Konecny; Diether Lambrechts; Lisa Rogmann; Pascal Guénel; Attila Teoman; Roger L Milne; Joaquin J Garcia; Angela Cox; Vijayalakshmi Shridhar; Barbara Burwinkel; Frederik Marme; Rebecca Hein; Elinor J Sawyer; Christopher A Haiman; Shan Wang-Gohrke; Irene L Andrulis; Kirsten B Moysich; John L Hopper; Kunle Odunsi; Annika Lindblom; Graham G Giles; Hermann Brenner; Jacques Simard; Galina Lurie; Peter A Fasching; Michael E Carney; Paolo Radice; Lynne R Wilkens; Anthony Swerdlow; Marc T Goodman; Hiltrud Brauch; Montserrat Garcia-Closas; Peter Hillemanns; Robert Winqvist; Matthias Dürst; Peter Devilee; Ingo Runnebaum; Anna Jakubowska; Jan Lubinski; Arto Mannermaa; Ralf Butzow; Natalia V Bogdanova; Thilo Dörk; Liisa M Pelttari; Wei Zheng; Arto Leminen; Hoda Anton-Culver; Clareann H Bunker; Vessela Kristensen; Roberta B Ness; Kenneth Muir; Robert Edwards; Alfons Meindl; Florian Heitz; Keitaro Matsuo; Andreas du Bois; Anna H Wu; Philipp Harter; Soo-Hwang Teo; Ira Schwaab; Xiao-Ou Shu; William Blot; Satoyo Hosono; Daehee Kang; Toru Nakanishi; Mikael Hartman; Yasushi Yatabe; Ute Hamann; Beth Y Karlan; Suleeporn Sangrajrang; Susanne Krüger Kjaer; Valerie Gaborieau; Allan Jensen; Diana Eccles; Estrid Høgdall; Chen-Yang Shen; Judith Brown; Yin Ling Woo; Mitul Shah; Mat Adenan Noor Azmi; Robert Luben; Siti Zawiah Omar; Kamila Czene; Robert A Vierkant; Børge G Nordestgaard; Henrik Flyger; Celine Vachon; Janet E Olson; Xianshu Wang; Douglas A Levine; Anja Rudolph; Rachel Palmieri Weber; Dieter Flesch-Janys; Edwin Iversen; Stefan Nickels; Joellen M Schildkraut; Isabel Dos Santos Silva; Daniel W Cramer; Lorna Gibson; Kathryn L Terry; Olivia Fletcher; Allison F Vitonis; C Ellen van der Schoot; Elizabeth M Poole; Frans B L Hogervorst; Shelley S Tworoger; Jianjun Liu; Elisa V Bandera; Jingmei Li; Sara H Olson; Keith Humphreys; Irene Orlow; Carl Blomqvist; Lorna Rodriguez-Rodriguez; Kristiina Aittomäki; Helga B Salvesen; Taru A Muranen; Elisabeth Wik; Barbara Brouwers; Camilla Krakstad; Els Wauters; Mari K Halle; Hans Wildiers; Lambertus A Kiemeney; Claire Mulot; Katja K Aben; Pierre Laurent-Puig; Anne Mvan Altena; Thérèse Truong; Leon F A G Massuger; Javier Benitez; Tanja Pejovic; Jose Ignacio Arias Perez; Maureen Hoatlin; M Pilar Zamora; Linda S Cook; Sabapathy P Balasubramanian; Linda E Kelemen; Andreas Schneeweiss; Nhu D Le; Christof Sohn; Angela Brooks-Wilson; Ian Tomlinson; Michael J Kerin; Nicola Miller; Cezary Cybulski; Brian E Henderson; Janusz Menkiszak; Fredrick Schumacher; Nicolas Wentzensen; Loic Le Marchand; Hannah P Yang; Anna Marie Mulligan; Gord Glendon; Svend Aage Engelholm; Julia A Knight; Claus K Høgdall; Carmel Apicella; Martin Gore; Helen Tsimiklis; Honglin Song; Melissa C Southey; Agnes Jager; Ans M Wvan den Ouweland; Robert Brown; John W M Martens; James M Flanagan; Mieke Kriege; James Paul; Sara Margolin; Nadeem Siddiqui; Gianluca Severi; Alice S Whittemore; Laura Baglietto; Valerie McGuire; Christa Stegmaier; Weiva Sieh; Heiko Müller; Volker Arndt; France Labrèche; Yu-Tang Gao; Mark S Goldberg; Gong Yang; Martine Dumont; John R McLaughlin; Arndt Hartmann; Arif B Ekici; Matthias W Beckmann; Catherine M Phelan; Michael P Lux; Jenny Permuth-Wey; Bernard Peissel; Thomas A Sellers; Filomena Ficarazzi; Monica Barile; Argyrios Ziogas; Alan Ashworth; Aleksandra Gentry-Maharaj; Michael Jones; Susan J Ramus; Nick Orr; Usha Menon; Celeste L Pearce; Thomas Brüning; Malcolm C Pike; Yon-Dschun Ko; Jolanta Lissowska; Jonine Figueroa; Jolanta Kupryjanczyk; Stephen J Chanock; Agnieszka Dansonka-Mieszkowska; Arja Jukkola-Vuorinen; Iwona K Rzepecka; Katri Pylkäs; Mariusz Bidzinski; Saila Kauppila; Antoinette Hollestelle; Caroline Seynaeve; Rob A E M Tollenaar; Katarzyna Durda; Katarzyna Jaworska; Jaana M Hartikainen; Veli-Matti Kosma; Vesa Kataja; Natalia N Antonenkova; Jirong Long; Martha Shrubsole; Sandra Deming-Halverson; Artitaya Lophatananon; Pornthep Siriwanarangsan; Sarah Stewart-Brown; Nina Ditsch; Peter Lichtner; Rita K Schmutzler; Hidemi Ito; Hiroji Iwata; Kazuo Tajima; Chiu-Chen Tseng; Daniel O Stram; David van den Berg; Cheng Har Yip; M Kamran Ikram; Yew-Ching Teh; Hui Cai; Wei Lu; Lisa B Signorello; Qiuyin Cai; Dong-Young Noh; Keun-Young Yoo; Hui Miao; Philip Tsau-Choong Iau; Yik Ying Teo; James McKay; Charles Shapiro; Foluso Ademuyiwa; George Fountzilas; Chia-Ni Hsiung; Jyh-Cherng Yu; Ming-Feng Hou; Catherine S Healey; Craig Luccarini; Susan Peock; Dominique Stoppa-Lyonnet; Paolo Peterlongo; Timothy R Rebbeck; Marion Piedmonte; Christian F Singer; Eitan Friedman; Mads Thomassen; Kenneth Offit; Thomas V O Hansen; Susan L Neuhausen; Csilla I Szabo; Ignacio Blanco; Judy Garber; Steven A Narod; Jeffrey N Weitzel; Marco Montagna; Edith Olah; Andrew K Godwin; Drakoulis Yannoukakos; David E Goldgar; Trinidad Caldes; Evgeny N Imyanitov; Laima Tihomirova; Banu K Arun; Ian Campbell; Arjen R Mensenkamp; Christi J van Asperen; Kees E P van Roozendaal; Hanne Meijers-Heijboer; J Margriet Collée; Jan C Oosterwijk; Maartje J Hooning; Matti A Rookus; Rob B van der Luijt; Theo A Mvan Os; D Gareth Evans; Debra Frost; Elena Fineberg; Julian Barwell; Lisa Walker; M John Kennedy; Radka Platte; Rosemarie Davidson; Steve D Ellis; Trevor Cole; Brigitte Bressac-de Paillerets; Bruno Buecher; Francesca Damiola; Laurence Faivre; Marc Frenay; Olga M Sinilnikova; Olivier Caron; Sophie Giraud; Sylvie Mazoyer; Valérie Bonadona; Virginie Caux-Moncoutier; Aleksandra Toloczko-Grabarek; Jacek Gronwald; Tomasz Byrski; Amanda B Spurdle; Bernardo Bonanni; Daniela Zaffaroni; Giuseppe Giannini; Loris Bernard; Riccardo Dolcetti; Siranoush Manoukian; Norbert Arnold; Christoph Engel; Helmut Deissler; Kerstin Rhiem; Dieter Niederacher; Hansjoerg Plendl; Christian Sutter; Barbara Wappenschmidt; Ake Borg; Beatrice Melin; Johanna Rantala; Maria Soller; Katherine L Nathanson; Susan M Domchek; Gustavo C Rodriguez; Ritu Salani; Daphne Gschwantler Kaulich; Muy-Kheng Tea; Shani Shimon Paluch; Yael Laitman; Anne-Bine Skytte; Torben A Kruse; Uffe Birk Jensen; Mark Robson; Anne-Marie Gerdes; Bent Ejlertsen; Lenka Foretova; Sharon A Savage; Jenny Lester; Penny Soucy; Karoline B Kuchenbaecker; Curtis Olswold; Julie M Cunningham; Susan Slager; Vernon S Pankratz; Ed Dicks; Sunil R Lakhani; Fergus J Couch; Per Hall; Alvaro N A Monteiro; Simon A Gayther; Paul D P Pharoah; Roger R Reddel; Ellen L Goode; Mark H Greene; Douglas F Easton; Andrew Berchuck; Antonis C Antoniou; Georgia Chenevix-Trench; Alison M Dunning Journal: Nat Genet Date: 2013-04 Impact factor: 38.330
Authors: John F Brothers; Kahkeshan Hijazi; Celine Mascaux; Randa A El-Zein; Margaret R Spitz; Avrum Spira Journal: BMC Med Date: 2013-07-19 Impact factor: 8.775