BACKGROUND: To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertile women with early stages of endometriosis. METHODS: We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject. RESULTS: No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. CONCLUSIONS: Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I-II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation.
BACKGROUND: To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertilewomen with early stages of endometriosis. METHODS: We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertilepatients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertilepatients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject. RESULTS: No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertilepatients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. CONCLUSIONS: Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I-II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation.
Authors: Marta Del Pino; Cecilia Svanholm-Barrie; Aureli Torné; Lorena Marimon; Jina Gaber; Amaia Sagasta; David H Persing; Jaume Ordi Journal: Mod Pathol Date: 2014-09-05 Impact factor: 7.842
Authors: Michele G Da Broi; Carlos V Rocha; Juliana Meola; Wellington P Martins; Filomena M Carvalho; Rui A Ferriani; Paula A Navarro Journal: JBRA Assist Reprod Date: 2017-09-01
Authors: Z He; Y Ma; L Li; J Liu; H Yang; C Chen; N Lin; Y Bai; R Ma; R Li; Z Wu; J Qiao Journal: Geburtshilfe Frauenheilkd Date: 2016-06 Impact factor: 2.915
Authors: Devashana Gupta; M Louise Hull; Ian Fraser; Laura Miller; Patrick M M Bossuyt; Neil Johnson; Vicki Nisenblat Journal: Cochrane Database Syst Rev Date: 2016-04-20
Authors: Fabio D'Amico; Evangelia Skarmoutsou; Giuseppe Quaderno; Grazia Malaponte; Carmelo La Corte; Giuseppe Scibilia; Gabriella D'Agate; Paolo Scollo; Filippo Fraggetta; Demetrios A Spandidos; Maria Clorinda Mazzarino Journal: Int J Mol Med Date: 2013-03-28 Impact factor: 4.101