Literature DB >> 22208896

Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology.

Arnold B Etame1, Roberto J Diaz, Christian A Smith, Todd G Mainprize, Kullervo Hynynen, James T Rutka.   

Abstract

Recent advances in molecular neurooncology provide unique opportunities for targeted molecular-based therapies. However, the blood-brain barrier (BBB) remains a major limitation to the delivery of tumor-specific therapies directed against aberrant signaling pathways in brain tumors. Given the dismal prognosis of patients with malignant brain tumors, novel strategies that overcome the intrinsic limitations of the BBB are therefore highly desirable. Focused ultrasound BBB disruption is emerging as a novel strategy for enhanced delivery of therapeutic agents into the brain via focal, reversible, and safe BBB disruption. This review examines the potential role and implications of focused ultrasound in molecular neurooncology.

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Year:  2012        PMID： 22208896      PMCID： PMC4106119          DOI： 10.3171/2011.10.FOCUS11252

Source DB:  PubMed          Journal:  Neurosurg Focus        ISSN： 1092-0684            Impact factor:   4.047


  79 in total

1.  Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier.

Authors:  Nickolai Sheikov; Nathan McDannold; Ferenc Jolesz; Yong-Zhi Zhang; Karen Tam; Kullervo Hynynen
Journal:  Ultrasound Med Biol       Date:  2006-09       Impact factor: 2.998

2.  Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.

Authors:  Kullervo Hynynen; Nathan McDannold; Natalia Vykhodtseva; Scott Raymond; Ralph Weissleder; Ferenc A Jolesz; Nickolai Sheikov
Journal:  J Neurosurg       Date:  2006-09       Impact factor: 5.115

3.  Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits.

Authors:  Nathan J McDannold; Natalia I Vykhodtseva; Kullervo Hynynen
Journal:  Radiology       Date:  2006-10       Impact factor: 11.105

Review 4.  The status of gene therapy for brain tumors.

Authors:  Giulia Fulci; E Antonio Chiocca
Journal:  Expert Opin Biol Ther       Date:  2007-02       Impact factor: 4.388

5.  Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery.

Authors:  Ryuta Saito; Michal T Krauze; Charles O Noble; Matyas Tamas; Daryl C Drummond; Dimitri B Kirpotin; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Journal:  J Neurosci Methods       Date:  2006-02-10       Impact factor: 2.390

6.  Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound.

Authors:  Lisa H Treat; Nathan McDannold; Natalia Vykhodtseva; Yongzhi Zhang; Karen Tam; Kullervo Hynynen
Journal:  Int J Cancer       Date:  2007-08-15       Impact factor: 7.396

7.  Phase II trial of intravenous lobradimil and carboplatin in childhood brain tumors: a report from the Children's Oncology Group.

Authors:  K Warren; R Jakacki; B Widemann; A Aikin; M Libucha; R Packer; G Vezina; G Reaman; D Shaw; M Krailo; C Osborne; J Cehelsky; D Caldwell; J Stanwood; S M Steinberg; F M Balis
Journal:  Cancer Chemother Pharmacol       Date:  2006-01-12       Impact factor: 3.333

8.  Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study.

Authors:  Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Journal:  Ultrasound Med Biol       Date:  2007-04       Impact factor: 2.998

9.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.

Authors:  Manabu Kinoshita; Nathan McDannold; Ferenc A Jolesz; Kullervo Hynynen
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-25       Impact factor: 11.205

10.  Particle size-dependent organ distribution of gold nanoparticles after intravenous administration.

Authors:  Wim H De Jong; Werner I Hagens; Petra Krystek; Marina C Burger; Adriënne J A M Sips; Robert E Geertsma
Journal:  Biomaterials       Date:  2008-02-01       Impact factor: 12.479
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  46 in total

Review 1.  High-Intensity Focused Ultrasound: Current Status for Image-Guided Therapy.

Authors:  Alexander Copelan; Jason Hartman; Monzer Chehab; Aradhana M Venkatesan
Journal:  Semin Intervent Radiol       Date:  2015-12       Impact factor: 1.513

Review 2.  Permeability imaging in pediatric brain tumors.

Authors:  Sandi Lam; Yimo Lin; Peter C Warnke
Journal:  Transl Pediatr       Date:  2014-07

3.  Alpha Particle Enhanced Blood Brain/Tumor Barrier Permeabilization in Glioblastomas Using Integrin Alpha-v Beta-3-Targeted Liposomes.

Authors:  Anirudh Sattiraju; Xiaobing Xiong; Darpan N Pandya; Thaddeus J Wadas; Ang Xuan; Yao Sun; Youngkyoo Jung; Kiran Kumar Solingapuram Sai; Jay F Dorsey; King C Li; Akiva Mintz
Journal:  Mol Cancer Ther       Date:  2017-06-15       Impact factor: 6.261

Review 4.  Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

Authors:  Darren Hargrave
Journal:  CNS Oncol       Date:  2012-11

Review 5.  Drug delivery systems, CNS protection, and the blood brain barrier.

Authors:  Ravi Kant Upadhyay
Journal:  Biomed Res Int       Date:  2014-07-20       Impact factor: 3.411

6.  Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model.

Authors:  Tatiana D Khokhlova; Yak-Nam Wang; Julianna C Simon; Bryan W Cunitz; Frank Starr; Marla Paun; Lawrence A Crum; Michael R Bailey; Vera A Khokhlova
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-19       Impact factor: 11.205

Review 7.  Transendothelial Transport and Its Role in Therapeutics.

Authors:  Ravi Kant Upadhyay
Journal:  Int Sch Res Notices       Date:  2014-08-27

8.  Numerical simulations of clinical focused ultrasound functional neurosurgery.

Authors:  Aki Pulkkinen; Beat Werner; Ernst Martin; Kullervo Hynynen
Journal:  Phys Med Biol       Date:  2014-03-12       Impact factor: 3.609

9.  Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery.

Authors:  Saira Alli; Carlyn A Figueiredo; Brian Golbourn; Nesrin Sabha; Megan Yijun Wu; Andrew Bondoc; Amanda Luck; Daniel Coluccia; Colin Maslink; Christian Smith; Heiko Wurdak; Kullervo Hynynen; Meaghan O'Reilly; James T Rutka
Journal:  J Control Release       Date:  2018-05-16       Impact factor: 9.776

10.  Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier.

Authors:  Xiaobing Xiong; Yao Sun; Anirudh Sattiraju; Youngkyoo Jung; Akiva Mintz; Satoru Hayasaka; King C P Li
Journal:  J Control Release       Date:  2015-08-31       Impact factor: 9.776
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