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Literature DB >> 2220824

The probabilistic determination of identity-by-descent sharing for pairs of relatives from pedigrees.

Abstract

Methods for detecting genetic linkage are more powerful when they fully use all of the data collected from pedigrees. We first discuss a method for obtaining the probability that a pedigree member has a given genotype, conditional on the phenotypes of his relatives. We then develop a rapid method to obtain the conditional probabilities of identity-by-descent sharing of marker alleles for all related pairs of individuals from extended pedigrees. The method assumes that the individuals are noninbred and that the relationship between genotype and phenotype is known for the marker locus studied. The probabilities of identity-by-descent sharing among relative pairs, conditional on marker phenotype information, can then be used in any of the model free tests for linkage between a trait locus and a marker locus.

Mesh：

Substances：
Genetic Markers

Year: 1990 PMID： 2220824 PMCID： PMC1683683

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

17 in total

1. The power of identity-by-state methods for linkage analysis.

Authors: D T Bishop; J A Williamson
Journal: Am J Hum Genet Date: 1990-02 Impact factor: 11.025

2. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

Authors: N Risch
Journal: Am J Hum Genet Date: 1990-02 Impact factor: 11.025

The probabilistic determination of identity-by-descent sharing for pairs of relatives from pedigrees.

1. The power of identity-by-state methods for linkage analysis.

2. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

3. Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.

4. Disease susceptibility genes--their identification by multiple case family studies.

5. The affected-pedigree-member method of linkage analysis.

6. The affected sib-pair method using identity by state relations.

7. A general model for the genetic analysis of pedigree data.

8. [The concept of identity and its importance in genetics].

9. A polymorphic DNA marker genetically linked to Huntington's disease.

10. The investigation of linkage between a quantitative trait and a marker locus.

Review 1. Linkage analysis in the next-generation sequencing era.

2. Genome-wide evaluation for quantitative trait loci under the variance component model.

3. Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients.

4. Nonparametric simulation-based statistics for detecting linkage in general pedigrees.

5. Multipoint quantitative-trait linkage analysis in general pedigrees.

6. Proportion of genome shared identical by descent by relatives: concept, computation, and applications.

7. Genotype relative risks: methods for design and analysis of candidate-gene association studies.

8. Gametogenesis processes and multilocus gene identity by descent.

9. Robust variance-components approach for assessing genetic linkage in pedigrees.

10. A quantitative linkage score for an association study following a linkage analysis.