| Literature DB >> 22207185 |
Mahtab Moayeri1, Inka Sastalla, Stephen H Leppla.
Abstract
Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models. Published by Elsevier Masson SAS.Entities:
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Year: 2011 PMID： 22207185 PMCID： PMC3322314 DOI： 10.1016/j.micinf.2011.12.005
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700