Literature DB >> 24766894

Inflammasomes and metabolic disorders: old genes in modern diseases.

Gregory R Robbins1, Haitao Wen2, Jenny P-Y Ting3.   

Abstract

Modern medical and hygienic practices have greatly improved human health and longevity; however, increased human life span occurs concomitantly with the emergence of metabolic and age-related diseases. Studies over the past decade have strongly linked host inflammatory responses to the etiology of several metabolic diseases including atherosclerosis, type 2 diabetes (T2D), obesity, and gout. A common immunological factor to these diseases is the activation of the inflammasome and release of proinflammatory cytokines that promote disease progression. Here we review the molecular mechanism(s) of inflammasome activation in response to metabolic damage-associated molecular patterns (DAMPs) and discuss potential targets for therapeutic intervention.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24766894      PMCID： PMC4084585          DOI： 10.1016/j.molcel.2014.03.029

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  114 in total

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Journal:  Immunity       Date:  2012-03-23       Impact factor: 31.745

Review 3.  Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

Authors:  Per Westermark; Arne Andersson; Gunilla T Westermark
Journal:  Physiol Rev       Date:  2011-07       Impact factor: 37.312

4.  Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.

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Journal:  Nat Immunol       Date:  2010-09-12       Impact factor: 25.606

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-29       Impact factor: 11.205

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Journal:  Hepatology       Date:  2003-04       Impact factor: 17.425

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Journal:  Curr Allergy Asthma Rep       Date:  2010-07       Impact factor: 4.806

9.  Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

Authors:  Zachary L Newman; Morton P Printz; Shihui Liu; Devorah Crown; Laura Breen; Sharmina Miller-Randolph; Pamela Flodman; Stephen H Leppla; Mahtab Moayeri
Journal:  PLoS Pathog       Date:  2010-05-20       Impact factor: 6.823

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Authors:  M J Nicklin; D E Hughes; J L Barton; J M Ure; G W Duff
Journal:  J Exp Med       Date:  2000-01-17       Impact factor: 14.307
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  47 in total

Review 1.  The danger model: questioning an unconvincing theory.

Authors:  Szczepan Józefowski
Journal:  Immunol Cell Biol       Date:  2015-07-28       Impact factor: 5.126

2.  Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Authors:  Rachel J Perry; João-Paulo G Camporez; Romy Kursawe; Paul M Titchenell; Dongyan Zhang; Curtis J Perry; Michael J Jurczak; Abulizi Abudukadier; Myoung Sook Han; Xian-Man Zhang; Hai-Bin Ruan; Xiaoyong Yang; Sonia Caprio; Susan M Kaech; Hei Sook Sul; Morris J Birnbaum; Roger J Davis; Gary W Cline; Kitt Falk Petersen; Gerald I Shulman
Journal:  Cell       Date:  2015-02-05       Impact factor: 41.582

Review 3.  Redox stress unbalances the inflammatory cytokine network: role in autoinflammatory patients and healthy subjects.

Authors:  Rosa Lavieri; Anna Rubartelli; Sonia Carta
Journal:  J Leukoc Biol       Date:  2015-07-21       Impact factor: 4.962

4.  Atheroma and the inflammasome.

Authors:  H William Strauss
Journal:  J Nucl Cardiol       Date:  2015-02-20       Impact factor: 5.952

5.  Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics.

Authors:  Yang Du; Qiannan Fang; Song-Guo Zheng
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 6.  Inflammasomes in Myeloid Cells: Warriors Within.

Authors:  Sushmita Jha; W June Brickey; Jenny Pan-Yun Ting
Journal:  Microbiol Spectr       Date:  2017-01

7.  SERPINB1-mediated checkpoint of inflammatory caspase activation.

Authors:  Youn Jung Choi; Stephanie Kim; Younho Choi; Travis B Nielsen; Jun Yan; Alvin Lu; Jianbin Ruan; Hye-Ra Lee; Hao Wu; Brad Spellberg; Jae U Jung
Journal:  Nat Immunol       Date:  2019-01-28       Impact factor: 25.606

8.  Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.

Authors:  K Schaale; K M Peters; A M Murthy; A K Fritzsche; M-D Phan; M Totsika; A A B Robertson; K B Nichols; M A Cooper; K J Stacey; G C Ulett; K Schroder; M A Schembri; M J Sweet
Journal:  Mucosal Immunol       Date:  2015-05-20       Impact factor: 7.313

9.  Breaking barriers: a GPCR triggers immunity in nematodes.

Authors:  Robert J Luallen; Emily R Troemel
Journal:  Nat Immunol       Date:  2014-09       Impact factor: 25.606

10.  Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Authors:  Joseph K Rathkey; Junjie Zhao; Zhonghua Liu; Yinghua Chen; Jie Yang; Hannah C Kondolf; Bryan L Benson; Steven M Chirieleison; Alex Y Huang; George R Dubyak; Tsan S Xiao; Xiaoxia Li; Derek W Abbott
Journal:  Sci Immunol       Date:  2018-08-24
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