Enrico T Nadres1, Olafs Daugulis. 1. Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
Abstract
A method for five- and six-membered heterocycle formation by palladium-catalyzed C-H/N-H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 °C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds.
A method for five- and six-membered heterocycle formation by n class="Chemical">palladiumn>-catalyzed C-H/N-H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 °C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds.
Authors: Kyle Clagg; Haiyun Hou; Adam B Weinstein; David Russell; Shannon S Stahl; Stefan G Koenig Journal: Org Lett Date: 2016-07-12 Impact factor: 6.005