A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.
A quinoline-based ligand was shown to promote n class="Chemical">palladium-catalyzed β-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.
Authors: Nicholas A Isley; Yusuke Endo; Zhi-Chen Wu; Brett C Covington; Leah B Bushin; Mohammad R Seyedsayamdost; Dale L Boger Journal: J Am Chem Soc Date: 2019-10-17 Impact factor: 15.419
Authors: Zhe Zhuang; Chang-Bin Yu; Gang Chen; Qing-Feng Wu; Yi Hsiao; Candice L Joe; Jennifer X Qiao; Michael A Poss; Jin-Quan Yu Journal: J Am Chem Soc Date: 2018-08-02 Impact factor: 15.419