Heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and agrochemicals. Therefore, the design of novel protocols to construct heterocycles more efficiently is a major area of focus in the organic chemistry. In the past several years, cyclization reactions based upon palladium-catalyzed C-H activation have received substantial attention due to their capacity for expediting heterocycle synthesis. This review discusses strategies for heterocycle synthesis via palladium-catalyzed C-H bond activation and highlights recent examples from the literature.
Heterocycliccompounds are ubiquitous in natural products, pharmaceuticals, and agrochemicals. Therefore, the design of novel protocols to construct heterocycles more efficiently is a major area of focus in the organicchemistry. In the past several years, cyclization reactions based upon panclass="Chemical">palladium-catalyzed C-H activation have received substantial attention due to their caclass="Chemical">pacity for expediting heterocycle synthesis. This review discusses strategies for heterocycle synthesis via class="Chemical">pan class="Chemical">palladium-catalyzed C-H bond activation and highlights recent examples from the literature.
Authors: Kyle Clagg; Haiyun Hou; Adam B Weinstein; David Russell; Shannon S Stahl; Stefan G Koenig Journal: Org Lett Date: 2016-07-12 Impact factor: 6.005
Authors: Liliana Damas; Rui M B Carrilho; Sandra C C Nunes; Alberto A C C Pais; László Kollár; Marta Pineiro; Mariette M Pereira Journal: R Soc Open Sci Date: 2018-09-12 Impact factor: 2.963