Literature DB >> 22190075

Organocatalytic enantioselective conjugate addition of ketones to isatylidine malononitriles.

Lu Liu1, Deyan Wu, Xiangmin Li, Sinan Wang, Hao Li, Jian Li, Wei Wang.   

Abstract

An enantioselective Michael addition of ketones to alkylidenemalononitriles catalyzed by chiral primary amine I with (R)-5c as a co-catalyst in good yields (>90%) and with good enantioselectivities (85-96% ee) has been developed. The strategy has also been extended to a three-component version through a domino Knoevenagel/Michael sequence with similar or better outcomes. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22190075     DOI： 10.1039/c2cc17067a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations.

Authors:  Alan R Burns; Amaël G E Madec; Darryl W Low; Iain D Roy; Hon Wai Lam
Journal:  Chem Sci       Date:  2015-04-30       Impact factor: 9.825

2.  Crystal structure and Hirshfeld surface analysis of 5-amino-5'-bromo-2'-oxo-2,3-di-hydro-1H-spiro-[imidazo[1,2-a]pyridine-7,3'-indoline]-6,8-dicarbo-nitrile dimethyl sulfoxide disolvate.

Authors:  Farid N Naghiyev; Victor N Khrustalev; Anton P Novikov; Mehmet Akkurt; Rovnag M Rzayev; Anzurat A Akobirshoeva; Ibrahim G Mamedov
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-05-10

3.  Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives.

Authors:  Akshay Kumar; Swapandeep Singh Chimni
Journal:  Beilstein J Org Chem       Date:  2014-04-24       Impact factor: 2.883
  3 in total

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