Leslie A Moroz1, Hyagriv N Simhan. 1. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Abstract
OBJECTIVE: We hypothesized that change in cervical length (CL) on serial ultrasounds is associated with spontaneous preterm birth (SPTB) <36 weeks for women with a short cervix (CL <25 mm). STUDY DESIGN: This was a secondary analysis of a multicenter prospective observational study designed to study predictors of preterm birth. Women from the general obstetric population had serial CL ultrasounds between 20-33 weeks' gestation and were followed up until delivery. RESULTS: Two thousand six hundred ninety five women had sonographic CL measurements. Change in CL was associated with SPTB for women with CL <25 mm (odds ratio, 0.97; 95% confidence interval, 0.96-0.98). Among women with a short cervix, for every 1 mm of cervical shortening between ultrasounds, there was a 3% increase in odds of SPTB. The association between change in CL and SPTB remained significant after controlling for age, race, body mass index, tobacco use, and fetal fibronectin test status. CONCLUSION: Among women with a sonographically short cervix, the rate of change in CL is associated with SPTB, independent of fetal fibronectin test and other important risk factors for SPTB. Published by Mosby, Inc.
OBJECTIVE: We hypothesized that change in cervical length (CL) on serial ultrasounds is associated with spontaneous preterm birth (SPTB) <36 weeks for women with a short cervix (CL <25 mm). STUDY DESIGN: This was a secondary analysis of a multicenter prospective observational study designed to study predictors of preterm birth. Women from the general obstetric population had serial CL ultrasounds between 20-33 weeks' gestation and were followed up until delivery. RESULTS: Two thousand six hundred ninety five women had sonographic CL measurements. Change in CL was associated with SPTB for women with CL <25 mm (odds ratio, 0.97; 95% confidence interval, 0.96-0.98). Among women with a short cervix, for every 1 mm of cervical shortening between ultrasounds, there was a 3% increase in odds of SPTB. The association between change in CL and SPTB remained significant after controlling for age, race, body mass index, tobacco use, and fetal fibronectin test status. CONCLUSION: Among women with a sonographically short cervix, the rate of change in CL is associated with SPTB, independent of fetal fibronectin test and other important risk factors for SPTB. Published by Mosby, Inc.
Authors: Andrea R Westervelt; Michael Fernandez; Michael House; Joy Vink; Chia-Ling Nhan-Chang; Ronald Wapner; Kristin M Myers Journal: J Biomech Eng Date: 2017-05-01 Impact factor: 2.097
Authors: P Wagner; J Sonek; M Heidemeyer; M Schmid; H Abele; M Hoopmann; K O Kagan Journal: Geburtshilfe Frauenheilkd Date: 2016-07 Impact factor: 2.915
Authors: Christine M O'Brien; Elizabeth Vargis; Bibhash C Paria; Kelly A Bennett; Anita Mahadevan-Jansen; Jeff Reese Journal: Acta Paediatr Date: 2014-04-17 Impact factor: 2.299
Authors: Lindsay M Kindinger; Maria Kyrgiou; David A MacIntyre; Stefano Cacciatore; Angela Yulia; Joanna Cook; Vasso Terzidou; T G Teoh; Phillip R Bennett Journal: PLoS One Date: 2016-11-03 Impact factor: 3.240