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Literature DB >> 22177962

Histone methylation makes its mark on longevity.

Abstract

How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Chromatin
Histones

Year: 2011 PMID： 22177962 PMCID： PMC3253950 DOI： 10.1016/j.tcb.2011.11.001

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

90 in total

1. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Authors: Jesper Christensen; Karl Agger; Paul A C Cloos; Diego Pasini; Simon Rose; Lau Sennels; Juri Rappsilber; Klaus H Hansen; Anna Elisabetta Salcini; Kristian Helin
Journal: Cell Date: 2007-02-22 Impact factor: 41.582

2. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.

Authors: Eric L Greer; Dara Dowlatshahi; Max R Banko; Judit Villen; Kimmi Hoang; Daniel Blanchard; Steven P Gygi; Anne Brunet
Journal: Curr Biol Date: 2007-09-27 Impact factor: 10.834

3. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

Authors: Mathieu Lupien; Jérôme Eeckhoute; Clifford A Meyer; Qianben Wang; Yong Zhang; Wei Li; Jason S Carroll; X Shirley Liu; Myles Brown
Journal: Cell Date: 2008-03-21 Impact factor: 41.582

4. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Authors: Young-Wook Cho; Teresa Hong; Sunhwa Hong; Hong Guo; Hong Yu; Doyeob Kim; Tad Guszczynski; Gregory R Dressler; Terry D Copeland; Markus Kalkum; Kai Ge
Journal: J Biol Chem Date: 2007-05-11 Impact factor: 5.157

Review 5. Sequence census methods for functional genomics.

Authors: Barbara Wold; Richard M Myers
Journal: Nat Methods Date: 2007-12-19 Impact factor: 28.547

6. Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1.

Authors: Mitsutoki Hatta; Lisa Ann Cirillo
Journal: J Biol Chem Date: 2007-10-08 Impact factor: 5.157

7. The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.

Authors: Joel C Eissenberg; Min Gyu Lee; Jessica Schneider; Anne Ilvarsonn; Ramin Shiekhattar; Ali Shilatifard
Journal: Nat Struct Mol Biol Date: 2007-03-11 Impact factor: 15.369

8. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.

Authors: Gawain McColl; David W Killilea; Alan E Hubbard; Maithili C Vantipalli; Simon Melov; Gordon J Lithgow
Journal: J Biol Chem Date: 2007-10-24 Impact factor: 5.157

9. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.

Authors: T Simonet; R Dulermo; S Schott; F Palladino
Journal: Dev Biol Date: 2007-10-29 Impact factor: 3.582

10. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.

Authors: Craig D Jude; Leslie Climer; Diyong Xu; Erika Artinger; Jill K Fisher; Patricia Ernst
Journal: Cell Stem Cell Date: 2007-09-13 Impact factor: 24.633

80 in total

1. NF-κB activation impairs somatic cell reprogramming in ageing.

Authors: Clara Soria-Valles; Fernando G Osorio; Ana Gutiérrez-Fernández; Alejandro De Los Angeles; Clara Bueno; Pablo Menéndez; José I Martín-Subero; George Q Daley; José M P Freije; Carlos López-Otín
Journal: Nat Cell Biol Date: 2015-07-27 Impact factor: 28.824

2. A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.

Authors: Joseph L McClay; Karolina A Aberg; Shaunna L Clark; Srilaxmi Nerella; Gaurav Kumar; Lin Y Xie; Alexandra D Hudson; Aki Harada; Christina M Hultman; Patrik K E Magnusson; Patrick F Sullivan; Edwin J C G Van Den Oord
Journal: Hum Mol Genet Date: 2013-10-16 Impact factor: 6.150

3. DNA methylome: Unveiling your biological age.

Authors: Ming Li; Wensu Liu; Tingting Yuan; Ruijun Bai; Guang-Hui Liu; Weizhou Zhang; Jing Qu
Journal: Protein Cell Date: 2013-10 Impact factor: 14.870

Review 4. The nexus of chromatin regulation and intermediary metabolism.

Authors: Philipp Gut; Eric Verdin
Journal: Nature Date: 2013-10-24 Impact factor: 49.962

Review 5. The Retrotransposon storm and the dangers of a Collyer's genome.

Authors: Josh Dubnau
Journal: Curr Opin Genet Dev Date: 2018-05-08 Impact factor: 5.578

6. RNA editing regulates transposon-mediated heterochromatic gene silencing.

Authors: Yiannis A Savva; James E C Jepson; Yao-Jen Chang; Rachel Whitaker; Brian C Jones; Georges St Laurent; Michael R Tackett; Philipp Kapranov; Nan Jiang; Guyu Du; Stephen L Helfand; Robert A Reenan
Journal: Nat Commun Date: 2013 Impact factor: 14.919