Literature DB >> 22148515

Combinatorial library of lipidoids for in vitro DNA delivery.

Shuo Sun1, Ming Wang, Sarah A Knupp, Yadira Soto-Feliciano, Xiao Hu, David L Kaplan, Robert Langer, Daniel G Anderson, Qiaobing Xu.   

Abstract

A combinatorial library of lipidoids was constructed and studied for in vitro gene delivery. The library of lipidoids was synthesized by reacting commercially available amines with lipophilic acrylates, acrylamides, or epoxides. Lipidoids derived from amine 86 (N,N-bis(2-hydroxyethyl)ethylene diamine) and amine 87 (N-(3-aminopropyl)diethaneamine) showed high efficiency in DNA delivery, some with a higher transfection efficiency than Lipofectamine 2000, a commonly used commercial gold standard for in vitro gene delivery. The structure-activity relationship between the lipidoids was further studied with respect to small variations in chemical structures and the resulting efficiency in DNA delivery in vitro. Since these lipidoids are easy to synthesize and do not require a colipid for efficient DNA delivery, they could offer an inexpensive but effective alternative to other commonly used commercial gene delivery carriers.

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Year:  2011        PMID： 22148515      PMCID： PMC3261308          DOI： 10.1021/bc200572w

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  10 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-11       Impact factor: 11.205

4.  Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.

Authors:  Kathryn A Whitehead; Gaurav Sahay; George Z Li; Kevin T Love; Christopher A Alabi; Minglin Ma; Christopher Zurenko; William Querbes; Robert S Langer; Daniel G Anderson
Journal:  Mol Ther       Date:  2011-07-12       Impact factor: 11.454

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8.  Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation.

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Journal:  Biochem Biophys Res Commun       Date:  2008-08-31       Impact factor: 3.575

9.  A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

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Journal:  Nat Biotechnol       Date:  2008-04-27       Impact factor: 54.908

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Authors:  Akin Akinc; Michael Goldberg; June Qin; J Robert Dorkin; Christina Gamba-Vitalo; Martin Maier; K Narayanannair Jayaprakash; Muthusamy Jayaraman; Kallanthottathil G Rajeev; Muthiah Manoharan; Victor Koteliansky; Ingo Röhl; Elizaveta S Leshchiner; Robert Langer; Daniel G Anderson
Journal:  Mol Ther       Date:  2009-03-03       Impact factor: 11.454
  10 in total
  19 in total

1.  A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration.

Authors:  Lei Sui; Ming Wang; Qianqian Han; Liming Yu; Lan Zhang; Leilei Zheng; Junxiang Lian; Jin Zhang; Paloma Valverde; Qiaobing Xu; Qisheng Tu; Jake Chen
Journal:  Biomaterials       Date:  2018-05-23       Impact factor: 12.479

2.  Preparation and Optimization of Lipid-Like Nanoparticles for mRNA Delivery.

Authors:  Bin Li; Yizhou Dong
Journal:  Methods Mol Biol       Date:  2017

Review 3.  Non-viral delivery of genome-editing nucleases for gene therapy.

Authors:  M Wang; Z A Glass; Q Xu
Journal:  Gene Ther       Date:  2016-10-31       Impact factor: 5.250

Review 4.  Transfection by cationic gemini lipids and surfactants.

Authors:  M Damen; A J J Groenen; S F M van Dongen; R J M Nolte; B J Scholte; M C Feiters
Journal:  Medchemcomm       Date:  2018-07-17       Impact factor: 3.597

5.  Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles.

Authors:  Ming Wang; John A Zuris; Fantao Meng; Holly Rees; Shuo Sun; Pu Deng; Yong Han; Xue Gao; Dimitra Pouli; Qi Wu; Irene Georgakoudi; David R Liu; Qiaobing Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

Review 6.  Engineered Hydrogels for Local and Sustained Delivery of RNA-Interference Therapies.

Authors:  Leo L Wang; Jason A Burdick
Journal:  Adv Healthc Mater       Date:  2016-12-15       Impact factor: 9.933

Review 7.  Lipid nanoparticles for gene delivery.

Authors:  Yi Zhao; Leaf Huang
Journal:  Adv Genet       Date:  2014       Impact factor: 1.944

8.  Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma.

Authors:  Christopher M Knapp; Jia He; John Lister; Kathryn A Whitehead
Journal:  Exp Biol Med (Maywood)       Date:  2016-03-27

9.  Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.

Authors:  Yizhou Dong; Ahmed A Eltoukhy; Christopher A Alabi; Omar F Khan; Omid Veiseh; J Robert Dorkin; Sasilada Sirirungruang; Hao Yin; Benjamin C Tang; Jeisa M Pelet; Delai Chen; Zhen Gu; Yuan Xue; Robert Langer; Daniel G Anderson
Journal:  Adv Healthc Mater       Date:  2014-03-13       Impact factor: 9.933

10.  siRNA targeting the κ light chain constant region: preclinical testing of an approach to nonfibrillar and fibrillar light chain deposition diseases.

Authors:  X Ma; P Zhou; S W Wong; M Warner; C Chaulagain; R L Comenzo
Journal:  Gene Ther       Date:  2016-06-20       Impact factor: 5.250
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