Literature DB >> 22139854

The use of an automated quantitative polymerase chain reaction (Xpert MTB/RIF) to predict the sputum smear status of tuberculosis patients.

Grant Theron1, Lancelot Pinto, Jonny Peter, Hemant Kumar Mishra, Hridesh Kumar Mishra, Richard van Zyl-Smit, Surendra Kumar Sharma, Keertan Dheda.   

Abstract

Xpert MTB/RIF-generated cycle-threshold (C(T)) values have poor clinical utility as a rule-in test for smear positivity (cut-point ≤20.2; sensitivity 32.3%, specificity 97.1%) but moderately good rule-out value (cut-point >31.8; negative predictive value 80.0%). Thus, 20% of individuals with C(T) values >31.8 were erroneously ruled out as smear-negative. This group had a significantly lower sputum bacillary load relative to correctly classified smear-positive patients (C(T) ≤ 31.8; P < .001). These data inform on public health and contact tracing strategies.

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Mesh：

Year:  2011        PMID： 22139854      PMCID： PMC3258275          DOI： 10.1093/cid/cir824

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  10 in total

1.  Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?

Authors:  Grant Theron; Anil Pooran; Jonny Peter; Richard van Zyl-Smit; Hridesh Kumar Mishra; Richard Meldau; Greg Calligaro; Brian Allwood; Surendra Kumar Sharma; Rod Dawson; Keertan Dheda
Journal:  Eur Respir J       Date:  2011-11-10       Impact factor: 16.671

2.  Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents.

Authors:  A H Diacon; J S Maritz; A Venter; P D van Helden; K Andries; D F McNeeley; P R Donald
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-09-04       Impact factor: 3.267

3.  Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples.

Authors:  Enrique F Schisterman; Neil J Perkins; Aiyi Liu; Howard Bondell
Journal:  Epidemiology       Date:  2005-01       Impact factor: 4.822

4.  Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting.

Authors:  Grant Theron; Jonny Peter; Richard van Zyl-Smit; Hridesh Mishra; Elizabeth Streicher; Samuel Murray; Rodney Dawson; Andrew Whitelaw; Michael Hoelscher; Surendra Sharma; Madhukar Pai; Robin Warren; Keertan Dheda
Journal:  Am J Respir Crit Care Med       Date:  2011-04-14       Impact factor: 21.405

5.  Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005.

Authors:  Paul A Jensen; Lauren A Lambert; Michael F Iademarco; Renee Ridzon
Journal:  MMWR Recomm Rep       Date:  2005-12-30

6.  Rapid molecular detection of tuberculosis and rifampin resistance.

Authors:  Catharina C Boehme; Pamela Nabeta; Doris Hillemann; Mark P Nicol; Shubhada Shenai; Fiorella Krapp; Jenny Allen; Rasim Tahirli; Robert Blakemore; Roxana Rustomjee; Ana Milovic; Martin Jones; Sean M O'Brien; David H Persing; Sabine Ruesch-Gerdes; Eduardo Gotuzzo; Camilla Rodrigues; David Alland; Mark D Perkins
Journal:  N Engl J Med       Date:  2010-09-01       Impact factor: 91.245

7.  Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli.

Authors:  M A Behr; S A Warren; H Salamon; P C Hopewell; A Ponce de Leon; C L Daley; P M Small
Journal:  Lancet       Date:  1999-02-06       Impact factor: 79.321

8.  Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV.

Authors:  R Dawson; P Masuka; D J Edwards; E D Bateman; L-G Bekker; R Wood; S D Lawn
Journal:  Int J Tuberc Lung Dis       Date:  2010-01       Impact factor: 2.373

9.  Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness.

Authors:  Kevin P Fennelly; John W Martyny; Kayte E Fulton; Ian M Orme; Donald M Cave; Leonid B Heifets
Journal:  Am J Respir Crit Care Med       Date:  2003-12-04       Impact factor: 21.405

10.  Time to detection of Mycobacterium tuberculosis in BACTEC systems as a viable alternative to colony counting.

Authors:  C Pheiffer; N M Carroll; N Beyers; P Donald; K Duncan; P Uys; P van Helden
Journal:  Int J Tuberc Lung Dis       Date:  2008-07       Impact factor: 2.373
  10 in total
  21 in total

1.  Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?

Authors:  Grant Theron; Anil Pooran; Jonny Peter; Richard van Zyl-Smit; Hridesh Kumar Mishra; Richard Meldau; Greg Calligaro; Brian Allwood; Surendra Kumar Sharma; Rod Dawson; Keertan Dheda
Journal:  Eur Respir J       Date:  2011-11-10       Impact factor: 16.671

2.  Xpert MTB/RIF Results in Patients With Previous Tuberculosis: Can We Distinguish True From False Positive Results?

Authors:  Grant Theron; Rouxjeane Venter; Greg Calligaro; Liezel Smith; Jason Limberis; Richard Meldau; Duncan Chanda; Aliasgar Esmail; Jonny Peter; Keertan Dheda
Journal:  Clin Infect Dis       Date:  2016-02-16       Impact factor: 9.079

3.  Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay.

Authors:  Yu Pang; Jie Lu; Biyi Su; Huiwen Zheng; Yanlin Zhao
Journal:  Infection       Date:  2017-07-13       Impact factor: 3.553

Review 4.  Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.

Authors:  Karen R Steingart; Ian Schiller; David J Horne; Madhukar Pai; Catharina C Boehme; Nandini Dendukuri
Journal:  Cochrane Database Syst Rev       Date:  2014-01-21

5.  Xpert MTB/RIF as a measure of sputum bacillary burden. Variation by HIV status and immunosuppression.

Authors:  Colleen F Hanrahan; Grant Theron; Jean Bassett; Keertan Dheda; Lesley Scott; Wendy Stevens; Ian Sanne; Annelies Van Rie
Journal:  Am J Respir Crit Care Med       Date:  2014-06-01       Impact factor: 21.405

6.  Testing Pooled Sputum with Xpert MTB/RIF for Diagnosis of Pulmonary Tuberculosis To Increase Affordability in Low-Income Countries.

Authors:  Saddiq T Abdurrahman; Omezikam Mbanaso; Lovett Lawson; Olanrewaju Oladimeji; Matthew Blakiston; Joshua Obasanya; Russell Dacombe; Emily R Adams; Nnamdi Emenyonu; Suvanand Sahu; Jacob Creswell; Luis E Cuevas
Journal:  J Clin Microbiol       Date:  2015-05-27       Impact factor: 5.948

7.  Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the GeneXpert MTB/RIF assay.

Authors:  Shubhada Shenai; Danielle Amisano; Katharina Ronacher; Magdalena Kriel; Padmapriya P Banada; Taeksun Song; Myungsun Lee; Joon Sung Joh; Jill Winter; Rich Thayer; Laura E Via; Soyeon Kim; Clifton E Barry; Gerhard Walzl; David Alland
Journal:  J Clin Microbiol       Date:  2013-10-09       Impact factor: 5.948

8.  Accuracy and impact of Xpert MTB/RIF for the diagnosis of smear-negative or sputum-scarce tuberculosis using bronchoalveolar lavage fluid.

Authors:  Grant Theron; Jonny Peter; Richard Meldau; Hoosain Khalfey; Phindile Gina; Brian Matinyena; Laura Lenders; Gregory Calligaro; Brian Allwood; Gregory Symons; Ureshnie Govender; Mashiko Setshedi; Keertan Dheda
Journal:  Thorax       Date:  2013-06-29       Impact factor: 9.139

9.  Multicenter feasibility study to assess external quality assessment panels for Xpert MTB/RIF assay in South Africa.

Authors:  Lesley Scott; Heidi Albert; Chris Gilpin; Heather Alexander; Kyle DeGruy; Wendy Stevens
Journal:  J Clin Microbiol       Date:  2014-04-30       Impact factor: 5.948

10.  EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa.

Authors:  George M Miiro; Odile Ouwe Missi Oukem-Boyer; Ousmane Sarr; Maerangis Rahmani; Francine Ntoumi; Keertan Dheda; Alexander Pym; Souleymane Mboup; Pontiano Kaleebu
Journal:  BMC Public Health       Date:  2013-03-22       Impact factor: 3.295
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