Literature DB >> 22139397

Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation.

Jinbao Xiang1, Hanghang Li, Kai Yang, Lang Yi, Yongnan Xu, Qun Dang, Xu Bai.   

Abstract

Highly substituted novel 4H-pyrimido[1,6-a] pyrimidines were prepared by a trifluoromethanesulfonic acid catalyzed one-pot three-component condensation of 4-aminopyrimidines, aldehydes, and β-ketoesters. A preliminary feasibility study was undertaken on these compounds, to assess the potential production of a library of further diversified compounds by nucleophilic replacement of Cl(R(1)) or by reaction of electrophiles with the NH(2)(R(2)) group.

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Year:  2011        PMID： 22139397     DOI： 10.1007/s11030-011-9345-y

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  23 in total

1.  Synthesis of novel 8,9-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7(6H)-ones.

Authors:  Jinbao Xiang; Dongsheng Wen; Hongxiang Xie; Qun Dang; Xu Bai
Journal:  J Comb Chem       Date:  2010-07-12

Review 2.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Allan J Goodman; Guillermo A Morales; Joseph M Salvino; Wei Zhang
Journal:  J Comb Chem       Date:  2007-09-19

3.  Kinase domain mutations in cancer: implications for small molecule drug design strategies.

Authors:  Jack A Bikker; Natasja Brooijmans; Allan Wissner; Tarek S Mansour
Journal:  J Med Chem       Date:  2009-03-26       Impact factor: 7.446

Review 4.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Allan J Goodman; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2008 Nov-Dec

5.  A cascade reaction consisting of Pictet-Spengler-type cyclization and Smiles rearrangement: application to the synthesis of novel pyrrole-fused dihydropteridines.

Authors:  Jinbao Xiang; Lianyou Zheng; Feng Chen; Qun Dang; Xu Bai
Journal:  Org Lett       Date:  2007-02-06       Impact factor: 6.005

6.  Diversity synthesis of pyrimido[4,5-b][1,6]naphthyridine and its derivatives under microwave irradiation.

Authors:  Zheng-Guo Han; Ge Zhang; Bo Jiang; Ning Ma; Feng Shi; Shu-Jiang Tu
Journal:  J Comb Chem       Date:  2009 Sep-Oct

7.  Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

Authors:  Christoph M Dehnhardt; Aranapakam M Venkatesan; Efren Delos Santos; Zecheng Chen; Osvaldo Santos; Semiramis Ayral-Kaloustian; Natasja Brooijmans; Robert Mallon; Irwin Hollander; Larry Feldberg; Judy Lucas; Inder Chaudhary; Ker Yu; Jay Gibbons; Robert Abraham; Tarek S Mansour
Journal:  J Med Chem       Date:  2010-01-28       Impact factor: 7.446

8.  Rapid access to pyrimido[5,4-c]isoquinolines via a sulfur monoxide extrusion reaction.

Authors:  Renzhong Fu; Xianxiu Xu; Qun Dang; Feng Chen; Xu Bai
Journal:  Org Lett       Date:  2007-02-15       Impact factor: 6.005

9.  Application of the modified Pictet-Spengler cyclization reaction for the preparation of an imidazopyrazine ring: synthesis of new pyrido- and pyrimido-imidazopyrazines.

Authors:  Sunil Sharma; Bijoy Kundu
Journal:  J Comb Chem       Date:  2009 Jul-Aug

10.  Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein.

Authors:  Nicola J Curtin; Hannah C Barlow; Karen J Bowman; A Hilary Calvert; Richard Davison; Bernard T Golding; Bing Huang; Peter J Loughlin; David R Newell; Peter G Smith; Roger J Griffin
Journal:  J Med Chem       Date:  2004-09-23       Impact factor: 7.446
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  2 in total

1.  Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening Approach.

Authors:  Jinbao Xiang; Zhuoqi Zhang; Yan Mu; Xianxiu Xu; Sigen Guo; Yongjin Liu; Daniel P Russo; Hao Zhu; Bing Yan; Xu Bai
Journal:  ACS Comb Sci       Date:  2016-04-15       Impact factor: 3.784

Review 2.  Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds.

Authors:  Khaled M Elattar; Başak Doğru Mert; M Monier; Ahmed El-Mekabaty
Journal:  RSC Adv       Date:  2020-04-20       Impact factor: 4.036
  2 in total

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