Literature DB >> 22139071

Targeting the epigenome for treatment of cancer.

E-J Geutjes1, P K Bajpe, R Bernards.   

Abstract

Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies.

Entities:  

Mesh：

Year:  2011        PMID： 22139071     DOI： 10.1038/onc.2011.552

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  30 in total

1.  RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

Authors:  J Huang; A Stewart; B Maity; J Hagen; R L Fagan; J Yang; D E Quelle; C Brenner; R A Fisher
Journal:  Oncogene       Date:  2013-09-02       Impact factor: 9.867

2.  Molecular docking and molecular dynamics study on SmHDAC1 to identify potential lead compounds against Schistosomiasis.

Authors:  Raghvendra Singh; Paras Nath Pandey
Journal:  Mol Biol Rep       Date:  2015-02-07       Impact factor: 2.316

Review 3.  Opportunities and challenges provided by crosstalk between signalling pathways in cancer.

Authors:  A Prahallad; R Bernards
Journal:  Oncogene       Date:  2015-05-18       Impact factor: 9.867

Review 4.  Epigenetic alterations of the Wnt signaling pathway in cancer: a mini review.

Authors:  Ljiljana Serman; Tamara Nikuseva Martic; Alan Serman; Semir Vranic
Journal:  Bosn J Basic Med Sci       Date:  2014-11-12       Impact factor: 3.363

5.  Generalized nucleation and looping model for epigenetic memory of histone modifications.

Authors:  Fabian Erdel; Eric C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-05       Impact factor: 11.205

Review 6.  Unprogrammed epigenetic variation mediated by stochastic formation of ectopic heterochromatin.

Authors:  Masato Sorida; Yota Murakami
Journal:  Curr Genet       Date:  2019-10-09       Impact factor: 3.886

7.  Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.

Authors:  Shou-Ping Dai; Chao Xie; Ning Ding; Yi-Jun Zhang; Lei Han; Yun-Wei Han
Journal:  Med Oncol       Date:  2015-04-30       Impact factor: 3.064

8.  Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Authors:  Jakob Lovén; Heather A Hoke; Charles Y Lin; Ashley Lau; David A Orlando; Christopher R Vakoc; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

9.  The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.

Authors:  J K Parrish; M Sechler; R A Winn; P Jedlicka
Journal:  Oncogene       Date:  2013-12-23       Impact factor: 9.867

10.  Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.

Authors:  W Yang; M T S Mok; M S M Li; W Kang; H Wang; A W Chan; J-L Chou; J Chen; E K W Ng; K-F To; J Yu; M W Y Chan; F K L Chan; J J Y Sung; A S L Cheng
Journal:  Oncogene       Date:  2015-07-27       Impact factor: 9.867
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