Literature DB >> 21995542

Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.

Ende Pan1, Alexander P Gorka, John N Alumasa, Carla Slebodnick, Liva Harinantenaina, Peggy J Brodie, Paul D Roepe, Richard Randrianaivo, Chris Birkinshaw, David G I Kingston.   

Abstract

Investigation of extracts from the plant Athroisma proteiforme (Humbert) Mattf. (Asteraceae) for antimalarial activity led to the isolation of the five new sesquiterpene lactones 1-5 together with centaureidin (6). The structures of the new compounds were deduced from analyses of physical and spectroscopic data, and the absolute configuration of compound 1 was confirmed by an X-ray crystallographic study. Athrolides C (3) and D (4) both showed antiplasmodial activities with IC50 values of 6.6 (3) and 7.2 μM (4) against the HB3 strain and 5.5 (3) and 4.2 μM (4) against the Dd2 strain of the malarial parasite Plasmodium falciparum. The isolates 1-6 also showed antiproliferative activity against A2780 human ovarian cancer cells, with IC50 values ranging from 0.4 to 2.5 μM.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21995542      PMCID： PMC3203994          DOI： 10.1021/np200499d

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  18 in total

1.  Two flavonoids and other compounds from the aerial parts of Centaurea bracteata from Italy.

Authors:  G Flamini; E Antognoli; I Morelli
Journal:  Phytochemistry       Date:  2001-06       Impact factor: 4.072

2.  Astrotricoumarin, an antiproliferative 4'-hydroxy-2',3'-dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest.

Authors:  Liva Harinantenaina; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Vincent E Rasamison; Etienne Rakotobe; David G I Kingston
Journal:  Nat Prod Commun       Date:  2011-09       Impact factor: 0.986

Review 3.  Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!

Authors:  T K Mutabingwa
Journal:  Acta Trop       Date:  2005-09       Impact factor: 3.112

4.  Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore.

Authors:  Pamisha Pillay; Robert Vleggaar; Vinesh J Maharaj; Peter J Smith; Carmen A Lategan; Frank Chouteau; Kelly Chibale
Journal:  Phytochemistry       Date:  2007-04-03       Impact factor: 4.072

5.  Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.

Authors:  Sojin An; Yong-Dae Park; Young-Ki Paik; Tae-Sook Jeong; Woo Song Lee
Journal:  Bioorg Med Chem Lett       Date:  2006-11-10       Impact factor: 2.823

6.  Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

Authors:  Tyler N Bennett; Michelle Paguio; Bojana Gligorijevic; Clement Seudieu; Andrew D Kosar; Eugene Davidson; Paul D Roepe
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

7.  In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.

Authors:  Eric Goffin; Eric Ziemons; Patrick De Mol; Maria do Céu de Madureira; Ana Paula Martins; Antonio Proença da Cunha; Geneviève Philippe; Monique Tits; Luc Angenot; Michel Frederich
Journal:  Planta Med       Date:  2002-06       Impact factor: 3.352

8.  Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

Authors:  K G Louie; B C Behrens; T J Kinsella; T C Hamilton; K R Grotzinger; W M McKoy; M A Winker; R F Ozols
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701

9.  The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum.

Authors:  Amal M M Nour; Sami A Khalid; Marcel Kaiser; Reto Brun; Wai'l E Abdallah; Thomas J Schmidt
Journal:  Planta Med       Date:  2009-05-08       Impact factor: 3.352

10.  Determination of absolute structure using Bayesian statistics on Bijvoet differences.

Authors:  Rob W W Hooft; Leo H Straver; Anthony L Spek
Journal:  J Appl Crystallogr       Date:  2008-01-16       Impact factor: 3.304
View more
  4 in total

1.  Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.

Authors:  Yumin Dai; Liva Harinantenaina; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; Yongchun Shen; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2011-12-02       Impact factor: 4.050

2.  Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar rain forest.

Authors:  Yumin Dai; Liva Harinantenaina; Peggy J Brodie; Martin W Callmander; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2012-10-23       Impact factor: 3.641

3.  Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts.

Authors:  Bojan Vujić; Vera Vidaković; Milka Jadranin; Irena Novaković; Snežana Trifunović; Vele Tešević; Boris Mandić
Journal:  Plants (Basel)       Date:  2020-03-06

4.  Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.

Authors:  Julia Krushkal; Simarjeet Negi; Laura M Yee; Jason R Evans; Tanja Grkovic; Alida Palmisano; Jianwen Fang; Hari Sankaran; Lisa M McShane; Yingdong Zhao; Barry R O'Keefe
Journal:  Mol Oncol       Date:  2020-11-24       Impact factor: 7.449
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.