S P Loh1, O Hadira. 1. Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. sploh@medic.upm.edu.my
Abstract
INTRODUCTION: This study was conducted to determine the inhibitory potential of selected Malaysian plants against key enzymes related to type 2 diabetes and hypertension. METHODS: The samples investigated were pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus), pegaga (Centella asiatica) and kacang botol (Psophocarpus tetragonolobus). The inhibitory potential of hexane and dichloromethane extracts against the enzymes were determined by using alpha-amylase, alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibition assay. RESULTS: In alpha-amylase inhibition assay, the inhibitory potential was highest in pucuk ubi for both hexane (59.22%) and dichloromethane extract (54.15%). Hexane extract of pucuk ubi (95.01%) and dichloromethane extract of kacang botol (38.94%) showed the highest inhibitory potential against alpha-glucosidase, while in ACE inhibition assay, the inhibitory potential was highest in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik (59.77%). CONCLUSION: This study suggests a nutraceutical potential of some of these plants for hyperglycemia and hypertension prevention associated with type 2 diabetes.
INTRODUCTION: This study was conducted to determine the inhibitory potential of selected Malaysian plants against key enzymes related to type 2 diabetes and hypertension. METHODS: The samples investigated were pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus), pegaga (Centella asiatica) and kacang botol (Psophocarpus tetragonolobus). The inhibitory potential of hexane and dichloromethane extracts against the enzymes were determined by using alpha-amylase, alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibition assay. RESULTS: In alpha-amylase inhibition assay, the inhibitory potential was highest in pucuk ubi for both hexane (59.22%) and dichloromethane extract (54.15%). Hexane extract of pucuk ubi (95.01%) and dichloromethane extract of kacang botol (38.94%) showed the highest inhibitory potential against alpha-glucosidase, while in ACE inhibition assay, the inhibitory potential was highest in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik (59.77%). CONCLUSION: This study suggests a nutraceutical potential of some of these plants for hyperglycemia and hypertension prevention associated with type 2 diabetes.
Authors: Mahanom Hussin; Azizah Abdul Hamid; Faridah Abas; Nurul Shazini Ramli; Ahmad Haniff Jaafar; Suri Roowi; Nordiana Abdul Majid; Mohd Sabri Pak Dek Journal: Molecules Date: 2019-09-03 Impact factor: 4.411
Authors: Khalid Mohammed Khan; Sridevi Chigurupati; Farman Ali; Munissa Younus; Maha Aldubayan; Abdul Wadood; Huma Khan; Muhammad Taha; Shahnaz Perveen Journal: ACS Omega Date: 2021-01-12