OBJECTIVE: To examine exercise testing response in Alzheimer's disease (AD) and possible disease-related change over time. DESIGN: Retrospective assessment of a 2-year observational study. SETTING: University medical center. PARTICIPANTS: Individuals without dementia (n=50) and with AD (n=31). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Participants underwent a clinical dementia evaluation and performed an incremental exercise test using a treadmill and the modified Bruce protocol at baseline and at a 2-year follow-up. We examined oxygen consumption, minute ventilation, heart rate, and ventilatory equivalents for oxygen and carbon dioxide at submaximal and peak exercise intensities to determine whether the measures were different between groups or over time. RESULTS: Participants with AD and those without dementia performed similarly at submaximal effort, and both groups showed similar changes in exercise response over 2 years. However, nondemented individuals had consistently higher values of oxygen consumption (P≤.02) and minute ventilation at peak effort at baseline (P=.003). CONCLUSIONS: Individuals with AD demonstrate physiologic responses to submaximal exercise effort that are not significantly different than individuals without dementia. However, differences are apparent at the extreme of effort.
OBJECTIVE: To examine exercise testing response in Alzheimer's disease (AD) and possible disease-related change over time. DESIGN: Retrospective assessment of a 2-year observational study. SETTING: University medical center. PARTICIPANTS: Individuals without dementia (n=50) and with AD (n=31). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Participants underwent a clinical dementia evaluation and performed an incremental exercise test using a treadmill and the modified Bruce protocol at baseline and at a 2-year follow-up. We examined oxygen consumption, minute ventilation, heart rate, and ventilatory equivalents for oxygen and carbon dioxide at submaximal and peak exercise intensities to determine whether the measures were different between groups or over time. RESULTS:Participants with AD and those without dementia performed similarly at submaximal effort, and both groups showed similar changes in exercise response over 2 years. However, nondemented individuals had consistently higher values of oxygen consumption (P≤.02) and minute ventilation at peak effort at baseline (P=.003). CONCLUSIONS: Individuals with AD demonstrate physiologic responses to submaximal exercise effort that are not significantly different than individuals without dementia. However, differences are apparent at the extreme of effort.
Authors: A F Kramer; S Hahn; N J Cohen; M T Banich; E McAuley; C R Harrison; J Chason; E Vakil; L Bardell; R A Boileau; A Colcombe Journal: Nature Date: 1999-07-29 Impact factor: 49.962
Authors: Stanley J Colcombe; Arthur F Kramer; Kirk I Erickson; Paige Scalf; Edward McAuley; Neal J Cohen; Andrew Webb; Gerry J Jerome; David X Marquez; Steriani Elavsky Journal: Proc Natl Acad Sci U S A Date: 2004-02-20 Impact factor: 11.205
Authors: R Ruscheweyh; C Willemer; K Krüger; T Duning; T Warnecke; J Sommer; K Völker; H V Ho; F Mooren; S Knecht; A Flöel Journal: Neurobiol Aging Date: 2009-08-29 Impact factor: 4.673
Authors: Eric D Vidoni; Anna Mattlage; Jonathan Mahnken; Jeffrey M Burns; Joe McDonough; Sandra A Billinger Journal: J Aging Phys Act Date: 2012-12-10 Impact factor: 1.961
Authors: Sandra A Billinger; Eric D Vidoni; Colby S Greer; Rasinio S Graves; Anna E Mattlage; Jeffrey M Burns Journal: Arch Phys Med Rehabil Date: 2014-04-26 Impact factor: 3.966
Authors: Eric D Vidoni; Amber S Watts; Jeffrey M Burns; Colby S Greer; Rasinio S Graves; Angela Van Sciver; Jessica R Black; Sarah K Cooper; Allison C Nagely; Elaine Uphoff; Jennifer M Volmer; Natalie A Bieberle Journal: J Alzheimers Dis Date: 2016-04-21 Impact factor: 4.472
Authors: Anna E Mattlage; Sara A Redlin; Lee R Rosterman; Nick Harn; Jason-Flor V Sisante; Michael G Abraham; Sandra A Billinger Journal: Cardiopulm Phys Ther J Date: 2016-07
Authors: Eric D Vidoni; Angela Van Sciver; David K Johnson; Jinghua He; Robyn Honea; Brian Haines; Jami Goodwin; M Pat Laubinger; Heather S Anderson; Patricia M Kluding; Joseph E Donnelly; Sandra A Billinger; Jeffrey M Burns Journal: Contemp Clin Trials Date: 2012-08-07 Impact factor: 2.226
Authors: Stephanie A Schultz; Elizabeth A Boots; Rodrigo P Almeida; Jennifer M Oh; Jean Einerson; Claudia E Korcarz; Dorothy F Edwards; Rebecca L Koscik; Maritza N Dowling; Catherine L Gallagher; Barbara B Bendlin; Bradley T Christian; Henrik Zetterberg; Kaj Blennow; Cynthia M Carlsson; Sanjay Asthana; Bruce P Hermann; Mark A Sager; Sterling C Johnson; James H Stein; Ozioma C Okonkwo Journal: J Int Neuropsychol Soc Date: 2015-11 Impact factor: 2.892
Authors: Martin Irmler; Romina J G Gentier; Frank J A Dennissen; Holger Schulz; Ines Bolle; Sabine M Hölter; Magdalena Kallnik; Jing Jun Cheng; Martin Klingenspor; Jan Rozman; Nicole Ehrhardt; Denise J H P Hermes; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Helmut E Meyer; David A Hopkins; Fred W Van Leeuwen; Johannes Beckers Journal: Acta Neuropathol Date: 2012-06-23 Impact factor: 17.088
Authors: Eric D Vidoni; David K Johnson; Jill K Morris; Angela Van Sciver; Colby S Greer; Sandra A Billinger; Joseph E Donnelly; Jeffrey M Burns Journal: PLoS One Date: 2015-07-09 Impact factor: 3.240