Sandra A Billinger1, Eric D Vidoni2, Colby S Greer2, Rasinio S Graves2, Anna E Mattlage3, Jeffrey M Burns2. 1. Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS. Electronic address: sbillinger@kumc.edu. 2. University of Kansas Alzheimer's Disease Center, Fairway, KS; Department of Neurology, University of Kansas Medical Center, Kansas City, KS. 3. Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS.
Abstract
OBJECTIVE: To retrospectively assess whether cardiopulmonary exercise testing would be well tolerated in individuals with Alzheimer disease (AD) compared with a nondemented peer group. DESIGN: We retrospectively reviewed 575 cardiopulmonary exercise tests (CPETs) in individuals with and without cognitive impairment caused by AD. SETTING: University medical center. PARTICIPANTS: Exercise tests (N=575) were reviewed for nondemented individuals (n=340) and those with AD-related cognitive impairment (n=235). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The main outcome measure for this study was reporting the reason for CPET termination. The hypothesis reported was formulated after data collection. RESULTS: We found that in cognitively impaired individuals, CPETs were terminated because of fall risk more often, but that overall test termination was infrequent-5.5% versus 2.1% (P=.04) in peers without cognitive impairment. We recorded 6 cardiovascular and 7 fall risk events in those with AD, compared with 7 cardiovascular and 0 fall risk events in those without cognitive impairment. CONCLUSIONS: Our findings support using CPETs to assess peak oxygen consumption in older adults with cognitive impairment caused by AD.
OBJECTIVE: To retrospectively assess whether cardiopulmonary exercise testing would be well tolerated in individuals with Alzheimer disease (AD) compared with a nondemented peer group. DESIGN: We retrospectively reviewed 575 cardiopulmonary exercise tests (CPETs) in individuals with and without cognitive impairment caused by AD. SETTING: University medical center. PARTICIPANTS: Exercise tests (N=575) were reviewed for nondemented individuals (n=340) and those with AD-related cognitive impairment (n=235). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The main outcome measure for this study was reporting the reason for CPET termination. The hypothesis reported was formulated after data collection. RESULTS: We found that in cognitively impaired individuals, CPETs were terminated because of fall risk more often, but that overall test termination was infrequent-5.5% versus 2.1% (P=.04) in peers without cognitive impairment. We recorded 6 cardiovascular and 7 fall risk events in those with AD, compared with 7 cardiovascular and 0 fall risk events in those without cognitive impairment. CONCLUSIONS: Our findings support using CPETs to assess peak oxygen consumption in older adults with cognitive impairment caused by AD.
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