AIM: To examine the association between intake of alcohol and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry. RESULTS: The eight-year incidence of asthma was 4.3%. After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p = 0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR = 1.59 (1.25-2.02), p = 0.000, whereas the risk of asthma in heavy daily drinkers (≥4 units/day) was also increased, however not statistically significant, OR = 1.13 (0.54-2.36), p = 0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3%) compared with beer preference (4.3%) or no preference (4.4%). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR = 0.87 (0.51-1.46), p = 0.590. CONCLUSION: Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma.
AIM: To examine the association between intake of alcohol and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry. RESULTS: The eight-year incidence of asthma was 4.3%. After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p = 0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR = 1.59 (1.25-2.02), p = 0.000, whereas the risk of asthma in heavy daily drinkers (≥4 units/day) was also increased, however not statistically significant, OR = 1.13 (0.54-2.36), p = 0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3%) compared with beer preference (4.3%) or no preference (4.4%). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR = 0.87 (0.51-1.46), p = 0.590. CONCLUSION:Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma.
Authors: Patricia F Coogan; Jeffrey Yu; George T O'Connor; Timothy A Brown; Yvette C Cozier; Julie R Palmer; Lynn Rosenberg Journal: Chest Date: 2014-03-01 Impact factor: 9.410
Authors: Solja T Nyberg; G David Batty; Jaana Pentti; Ida E H Madsen; Lars Alfredsson; Jakob B Bjorner; Marianne Borritz; Hermann Burr; Jenni Ervasti; Marcel Goldberg; Markus Jokela; Anders Knutsson; Aki Koskinen; Tea Lallukka; Joni V Lindbohm; Martin L Nielsen; Tuula Oksanen; Jan H Pejtersen; Olli Pietiläinen; Ossi Rahkonen; Reiner Rugulies; Martin J Shipley; Pyry N Sipilä; Jeppe K Sørensen; Sari Stenholm; Sakari Suominen; Ari Väänänen; Jussi Vahtera; Marianna Virtanen; Hugo Westerlund; Marie Zins; Archana Singh-Manoux; Mika Kivimäki Journal: Lancet Reg Health Eur Date: 2022-05-29
Authors: Tea Skaaby; Tuomas O Kilpeläinen; Amy E Taylor; Yuvaraj Mahendran; Andrew Wong; Tarunveer S Ahluwalia; Lavinia Paternoster; Stella Trompet; David J Stott; Claudia Flexeder; Ang Zhou; Guy Brusselle; Ayesha Sajjad; Lies Lahousse; Henning Tiemeier; Christian Theil Have; Betina H Thuesen; Line Lund Kårhus; Line Tang Møllehave; Katja Biering Leth-Møller; Daniel Mønsted Shabanzadeh; Arturo Gonzalez-Quintela; Chris Power; Elina Hyppönen; Diana Kuh; Rebecca Hardy; Thomas Meitinger; J Wouter Jukema; Uwe Völker; Matthias Nauck; Henry Völzke; Nele Friedrich; Tobias N Bonten; Raymond Noordam; Dennis O Mook-Kanamori; Janne S Tolstrup; Christian Taube; Annette Peters; Harald Grallert; Konstantin Strauch; Holger Schulz; Niels Grarup; Torben Hansen; Oluf Pedersen; Stephen Burgess; Marcus R Munafò; Allan Linneberg Journal: Addiction Date: 2018-10-30 Impact factor: 7.256
Authors: Ana Maria Baptista Menezes; Bruna Celestino Schneider; Vânia Pereira Oliveira; Fernanda Barros Prieto; Deisi Lane Rodrigues Silva; Beatriz Raffi Lerm; Thielen Borba da Costa; Roberta Bouilly; Fernando C Wehrmeister; Helen Gonçalves; Maria Cecília Formoso Assunção Journal: J Asthma Allergy Date: 2020-10-14