Tea Skaaby1, Tuomas O Kilpeläinen2, Amy E Taylor3,4, Yuvaraj Mahendran2, Andrew Wong5, Tarunveer S Ahluwalia2,6, Lavinia Paternoster3, Stella Trompet7,8, David J Stott9, Claudia Flexeder10, Ang Zhou11, Guy Brusselle12,13, Ayesha Sajjad12, Lies Lahousse12,13, Henning Tiemeier12,14, Christian Theil Have2, Betina H Thuesen1, Line Lund Kårhus1, Line Tang Møllehave1, Katja Biering Leth-Møller1, Daniel Mønsted Shabanzadeh1, Arturo Gonzalez-Quintela15, Chris Power16, Elina Hyppönen11,16,17, Diana Kuh5, Rebecca Hardy5, Thomas Meitinger18,19, J Wouter Jukema7,20, Uwe Völker21, Matthias Nauck22, Henry Völzke23, Nele Friedrich1,22, Tobias N Bonten24,25, Raymond Noordam8, Dennis O Mook-Kanamori25,26, Janne S Tolstrup27, Christian Taube28, Annette Peters10,29, Harald Grallert29,30, Konstantin Strauch31,32, Holger Schulz10,33, Niels Grarup2, Torben Hansen2, Oluf Pedersen2, Stephen Burgess34,35, Marcus R Munafò3,4, Allan Linneberg1,36,37. 1. Center for Clinical Research and Prevention, Frederiksberg and Bispebjerg Hospital, Frederiksberg, Denmark. 2. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 3. MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK. 4. UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK. 5. MRC Unit for Lifelong Health and Ageing at UCL, London, UK. 6. Steno Diabetes Center Copenhagen, Gentofte, Denmark. 7. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. 8. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands. 9. Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, UK. 10. Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 11. Centre for Population Health Research, School of Health Sciences and Sansom Institute of Health Research, University of South Australia, Adelaide, Australia. 12. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. 13. Department of Bioanalysis, FFW, Ghent University, Ghent, Belgium. 14. Department of Child- and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands. 15. Department of Internal Medicine, Hospital and University of Santiago de Compostela, Santiago de Compostela, Spain. 16. Population, Policy and Practice, UCL Great Ormond Street Hospital Institute of Child Health, University College London, London, UK. 17. South Australian Health and Medical Research Institute, Adelaide, Australia. 18. Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 19. Institute of Human Genetics, Technische Universität München, Munich, Germany. 20. Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, the Netherlands. 21. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Germany. 22. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany. 23. Institute for Community Medicine, University Medicine Greifswald, Germany. 24. Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands. 25. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. 26. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 27. National Institute of Public Health, University of Southern, Denmark. 28. Department of Pulmonary Medicine, University Medical Center Essen Ruhrlandklinik, Essen, Germany. 29. Research Unit Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. 30. German Center for Diabetes Research (DZD), Neuherberg, Germany. 31. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 32. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. 33. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, München, Germany. 34. MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. 35. Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 36. Department of Clinical Experimental Research, Rigshospitalet, Denmark. 37. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. SETTING: Europe. PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015. MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples. FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE. CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. SETTING: Europe. PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015. MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples. FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE. CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
Authors: Kristian Assing; Uffe Bodtger; Allan Linneberg; Hans Jørgen Malling; Lars K Poulsen Journal: Ann Allergy Asthma Immunol Date: 2007-01 Impact factor: 6.347
Authors: A Gonzalez-Quintela; M Garrido; F Gude; J Campos; A Linneberg; S Lojo; C Vidal Journal: Clin Exp Allergy Date: 2007-11-02 Impact factor: 5.018
Authors: Qi Yi Ambrose Wong; Jun Jie Lim; Jun Yan Ng; Praneeth Malipeddi; Wei Yi Teo; Yi Ying Eliza Lim; Yu Ting Ng; Yang Yie Sio; Sri Anusha Matta; Yi Ru Wong; Keng Foo Teh; Smyrna Moti Rawanan Shah; Kavita Reginald; Yee How Say; Fook Tim Chew Journal: World Allergy Organ J Date: 2022-10-07 Impact factor: 5.516