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Literature DB >> 22125584

Chlorinated Withanolides from Withania somnifera.

Xiaoqin Tong¹, Huaping Zhang, Barbara N Timmermann.

Abstract

A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were isolated from Withania somnifera (Solanaceae). All structures were elucidated on the basis of spectroscopic methods (IR, HRESIMS, 1D/2D NMR). X-ray crystallography confirmed the absolute configuration of 1.

Entities: Chemical Disease Species

Year: 2011 PMID： 22125584 PMCID： PMC3223914 DOI： 10.1016/j.phytol.2011.04.016

Source DB: PubMed Journal: Phytochem Lett ISSN： 1874-3900 Impact factor: 1.679

16 in total

1. Anticarcinogenic activity of Withania somnifera Dunal against Dalton's ascitic lymphoma.

Authors: A J M Christina; D Gladwin Joseph; M Packialakshmi; R Kothai; S Jerry Heison Robert; N Chidambaranathan; M Ramasamy
Journal: J Ethnopharmacol Date: 2004-08 Impact factor: 4.360

2. Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma.

Authors: Abbas K Samadi; Xiaoqin Tong; Ridhwi Mukerji; Huaping Zhang; Barbara N Timmermann; Mark S Cohen
Journal: J Nat Prod Date: 2010-09-24 Impact factor: 4.050

3. Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum.

Authors: H Matsuda; T Murakami; A Kishi; M Yoshikawa
Journal: Bioorg Med Chem Date: 2001-06 Impact factor: 3.641

4. Immunomodulatory activity of Withania somnifera.

Authors: L Davis; G Kuttan
Journal: J Ethnopharmacol Date: 2000-07 Impact factor: 4.360

5. Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis.

Authors: M Owais; K S Sharad; A Shehbaz; M Saleemuddin
Journal: Phytomedicine Date: 2005-03 Impact factor: 5.340

6. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs.

Authors: J N Dhuley
Journal: J Ethnopharmacol Date: 2000-04 Impact factor: 4.360

7. Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.

Authors: Jing Zhao; Norio Nakamura; Masao Hattori; Tomoharu Kuboyama; Chihiro Tohda; Katsuko Komatsu
Journal: Chem Pharm Bull (Tokyo) Date: 2002-06 Impact factor: 1.645

8. Anti-inflammatory activity of some Iraqi plants using intact rats.

Authors: M K Al-Hindawi; I H Al-Deen; M H Nabi; M A Ismail
Journal: J Ethnopharmacol Date: 1989-09 Impact factor: 4.360

9. Antioxidant activity of glycowithanolides from Withania somnifera.

Authors: S K Bhattacharya; K S Satyan; S Ghosal
Journal: Indian J Exp Biol Date: 1997-03 Impact factor: 0.818

10. The in vitro antibacterial/synergistic activities of Withania somnifera extracts.

Authors: S Arora; S Dhillon; G Rani; A Nagpal
Journal: Fitoterapia Date: 2004-06 Impact factor: 2.882

11 in total

1. Withanolides from Jaborosa caulescens var. bipinnatifida.

Authors: Huaping Zhang; Cong-Mei Cao; Robert J Gallagher; Victor W Day; Gloria Montenegro; Barbara N Timmermann
Journal: Phytochemistry Date: 2013-12-05 Impact factor: 4.072

2. Cytotoxic withanolide constituents of Physalis longifolia.

Authors: Huaping Zhang; Abbas K Samadi; Robert J Gallagher; Juan J Araya; Xiaoqin Tong; Victor W Day; Mark S Cohen; Kelly Kindscher; Rao Gollapudi; Barbara N Timmermann
Journal: J Nat Prod Date: 2011-11-18 Impact factor: 4.050

3. Minor withanolides of Physalis longifolia: structure and cytotoxicity.

Authors: Huaping Zhang; Hashim Motiwala; Abbas Samadi; Victor Day; Jeffrey Aubé; Mark Cohen; Kelly Kindscher; Rao Gollapudi; Barbara Timmermann
Journal: Chem Pharm Bull (Tokyo) Date: 2012 Impact factor: 1.645

4. Antiproliferative withanolides from Datura wrightii.

Authors: Huaping Zhang; Joseph Bazzill; Robert J Gallagher; Chitra Subramanian; Patrick T Grogan; Victor W Day; Kelly Kindscher; Mark S Cohen; Barbara N Timmermann
Journal: J Nat Prod Date: 2012-12-19 Impact factor: 4.050

Review 5. Antiproliferative withanolides from several solanaceous species.

Authors: Huaping Zhang; Cong-Mei Cao; Robert J Gallagher; Barbara N Timmermann
Journal: Nat Prod Res Date: 2014-05-28 Impact factor: 2.861

6. Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor.

Authors: Manish Kumar Tripathi; Pushpendra Singh; Sujata Sharma; Tej P Singh; A S Ethayathulla; Punit Kaur
Journal: J Biomol Struct Dyn Date: 2020-07-08

Review 7. Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective.

Authors: Sumaira Saleem; Gulzar Muhammad; Muhammad Ajaz Hussain; Muhammad Altaf; Syed Nasir Abbas Bukhari
Journal: Iran J Basic Med Sci Date: 2020-12 Impact factor: 2.699

8. Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl.

Authors: Ya-Ming Xu; E M Kithsiri Wijeratne; Manping X Liu; Lijiang Xuan; Wenqiong Wang; A A Leslie Gunatilaka
Journal: Molecules Date: 2022-01-28 Impact factor: 4.411

9. Anti-proliferative withanolides from the Solanaceae: a structure-activity study.

Authors: Huaping Zhang; Abbas K Samadi; Mark S Cohen; Barbara N Timmermann
Journal: Pure Appl Chem Date: 2012 Impact factor: 2.453

10. Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells.

Authors: Al Hassan Kyakulaga; Farrukh Aqil; Radha Munagala; Ramesh C Gupta
Journal: Sci Rep Date: 2018-10-24 Impact factor: 4.379