Literature DB >> 22124370

Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

Hongtao Zhang1, Yan Xiao, Zhiqiang Zhu, Bin Li, Mark I Greene.   

Abstract

Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system homeostasis and tolerance to self and foreign antigens, the body's response to cancer and infectious agents. FOXP3 forms oligomeric complexes with other proteins, the components of which are believed to be regulated dynamically. In addition, HDAC activities influence FOXP3 interactions with other partners to form transcriptional regulatory complexes. By understanding the details of the biochemical and structural basis of the regulation of FOXP3 acetylation, therapeutic strategies for diseases related to Treg cells may emerge.

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Year:  2011        PMID： 22124370      PMCID： PMC3366555          DOI： 10.1038/icb.2011.101

Source DB:  PubMed          Journal:  Immunol Cell Biol        ISSN： 0818-9641            Impact factor:   5.126


  61 in total

1.  Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors.

Authors:  Julie L Lucas; Parham Mirshahpanah; Eric Haas-Stapleton; Khusru Asadullah; Thomas M Zollner; Robert P Numerof
Journal:  Cell Immunol       Date:  2009-04-08       Impact factor: 4.868

2.  Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells.

Authors:  Andriana Margariti; Qingzhong Xiao; Anna Zampetaki; Zhongyi Zhang; Hongling Li; Daniel Martin; Yanhua Hu; Lingfang Zeng; Qingbo Xu
Journal:  J Cell Sci       Date:  2009-01-27       Impact factor: 5.285

Review 3.  HDAC inhibitor-based therapies and haematological malignancy.

Authors:  L Stimson; V Wood; O Khan; S Fotheringham; N B La Thangue
Journal:  Ann Oncol       Date:  2009-06-10       Impact factor: 32.976

4.  Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.

Authors:  Anja Schuetz; Jinrong Min; Abdellah Allali-Hassani; Matthieu Schapira; Michael Shuen; Peter Loppnau; Ralph Mazitschek; Nick P Kwiatkowski; Timothy A Lewis; Rebecca L Maglathin; Thomas H McLean; Alexey Bochkarev; Alexander N Plotnikov; Masoud Vedadi; Cheryl H Arrowsmith
Journal:  J Biol Chem       Date:  2008-02-19       Impact factor: 5.157

5.  Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.

Authors:  Jianguang Du; Chunjian Huang; Baohua Zhou; Steven F Ziegler
Journal:  J Immunol       Date:  2008-04-01       Impact factor: 5.422

6.  Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

Authors:  Zhibin Wang; Chongzhi Zang; Kairong Cui; Dustin E Schones; Artem Barski; Weiqun Peng; Keji Zhao
Journal:  Cell       Date:  2009-08-20       Impact factor: 41.582

7.  Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.

Authors:  Sandra J Saouaf; Bin Li; Geng Zhang; Yuan Shen; Narumi Furuuchi; Wayne W Hancock; Mark I Greene
Journal:  Exp Mol Pathol       Date:  2009-07-03       Impact factor: 3.362

8.  The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.

Authors:  Jinping Zhang; Sang-Myeong Lee; Stephen Shannon; Beixue Gao; Weimin Chen; An Chen; Rohit Divekar; Michael W McBurney; Helen Braley-Mullen; Habib Zaghouani; Deyu Fang
Journal:  J Clin Invest       Date:  2009-10       Impact factor: 14.808

9.  Three distinct domains contribute to nuclear transport of murine Foxp3.

Authors:  Wayne W Hancock; Engin Ozkaynak
Journal:  PLoS One       Date:  2009-11-18       Impact factor: 3.240

10.  Degradation of cyclin A is regulated by acetylation.

Authors:  F Mateo; M Vidal-Laliena; N Canela; L Busino; M A Martinez-Balbas; M Pagano; N Agell; O Bachs
Journal:  Oncogene       Date:  2009-06-01       Impact factor: 9.867
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  15 in total

1.  Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.

Authors:  Guoping Deng; Yasuhiro Nagai; Yan Xiao; Zhiyuan Li; Shujia Dai; Takuya Ohtani; Alison Banham; Bin Li; Shiaw-Lin Wu; Wayne Hancock; Arabinda Samanta; Hongtao Zhang; Mark I Greene
Journal:  J Biol Chem       Date:  2015-05-18       Impact factor: 5.157

2.  Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo.

Authors:  Nicole L Regna; Cristen B Chafin; Sarah E Hammond; Abdul G Puthiyaveetil; David L Caudell; Christopher M Reilly
Journal:  Clin Immunol       Date:  2014-01-15       Impact factor: 3.969

Review 3.  Type 3 regulatory T cells at the interface of symbiosis.

Authors:  Joo-Hong Park; Gérard Eberl
Journal:  J Microbiol       Date:  2018-02-28       Impact factor: 3.422

Review 4.  Forkhead box proteins: tuning forks for transcriptional harmony.

Authors:  Eric W-F Lam; Jan J Brosens; Ana R Gomes; Chuay-Yeng Koo
Journal:  Nat Rev Cancer       Date:  2013-07       Impact factor: 60.716

5.  Correlation between Histone Deacetylase 9 and Regulatory T Cell in Patients with Chronic Heart Failure.

Authors:  Ping-Ping Liao; Li-Hua Liu; Bin Wang; Xin Fang; Shao-Qiong Zhou; Wei Li; Yan-Qing Zhang; Si-Ming Guan
Journal:  Curr Med Sci       Date:  2018-04-30

Review 6.  Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.

Authors:  Guoping Deng; Yan Xiao; Zhaocai Zhou; Yasuhiro Nagai; Hongtao Zhang; Bin Li; Mark I Greene
Journal:  Exp Mol Pathol       Date:  2012-10-02       Impact factor: 3.362

7.  The plasticity and stability of regulatory T cells.

Authors:  Shimon Sakaguchi; Dario A A Vignali; Alexander Y Rudensky; Rachel E Niec; Herman Waldmann
Journal:  Nat Rev Immunol       Date:  2013-05-17       Impact factor: 53.106

Review 8.  Anatomical localization of commensal bacteria in immune cell homeostasis and disease.

Authors:  Thomas C Fung; David Artis; Gregory F Sonnenberg
Journal:  Immunol Rev       Date:  2014-07       Impact factor: 12.988

9.  Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers.

Authors:  Taofeng Du; Yasuhiro Nagai; Yan Xiao; Mark I Greene; Hongtao Zhang
Journal:  Exp Mol Pathol       Date:  2013-05-02       Impact factor: 3.362

10.  Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.

Authors:  Yan Xiao; Yasuhiro Nagai; Guoping Deng; Takuya Ohtani; Zhiqiang Zhu; Zhaocai Zhou; Hongtao Zhang; Mei Q Ji; John W Lough; Arabinda Samanta; Wayne W Hancock; Mark I Greene
Journal:  Cell Rep       Date:  2014-05-15       Impact factor: 9.423
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