Literature DB >> 23681097

The plasticity and stability of regulatory T cells.

Shimon Sakaguchi1, Dario A A Vignali, Alexander Y Rudensky, Rachel E Niec, Herman Waldmann.   

Abstract

Regulatory T (TReg) cells are crucial for the prevention of fatal autoimmunity in mice and humans. Forkhead box P3 (FOXP3)(+) TReg cells are produced in the thymus and are also generated from conventional CD4(+) T cells in peripheral sites. It has been suggested that FOXP3(+) TReg cells might become unstable under certain inflammatory conditions and might adopt a phenotype that is more characteristic of effector CD4(+) T cells. These suggestions have caused considerable debate in the field and have important implications for the therapeutic use of TReg cells. In this article, Nature Reviews Immunology asks several experts for their views on the plasticity and stability of TReg cells.

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Year:  2013        PMID： 23681097     DOI： 10.1038/nri3464

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  48 in total

1.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

Authors:  Naganari Ohkura; Masahide Hamaguchi; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Hans Joerg Fehling; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi
Journal:  Immunity       Date:  2012-11-01       Impact factor: 31.745

2.  Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells.

Authors:  Eva d'Hennezel; Ekaterina Yurchenko; Evridiki Sgouroudis; Valérie Hay; Ciriaco A Piccirillo
Journal:  J Immunol       Date:  2011-05-16       Impact factor: 5.422

3.  Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.

Authors:  Ulf H Beier; Liqing Wang; Rongxiang Han; Tatiana Akimova; Yujie Liu; Wayne W Hancock
Journal:  Sci Signal       Date:  2012-06-19       Impact factor: 8.192

4.  Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.

Authors:  G Lal; N Yin; J Xu; M Lin; S Schroppel; Y Ding; I Marie; D E Levy; J S Bromberg
Journal:  Am J Transplant       Date:  2011-01-10       Impact factor: 8.086

Review 5.  Regulatory T cells and cancer.

Authors:  Helen Y Wang; Rong-Fu Wang
Journal:  Curr Opin Immunol       Date:  2007-02-15       Impact factor: 7.486

6.  Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

Authors:  Gang Wei; Lai Wei; Jinfang Zhu; Chongzhi Zang; Jane Hu-Li; Zhengju Yao; Kairong Cui; Yuka Kanno; Tae-Young Roh; Wendy T Watford; Dustin E Schones; Weiqun Peng; Hong-Wei Sun; William E Paul; John J O'Shea; Keji Zhao
Journal:  Immunity       Date:  2009-01-16       Impact factor: 31.745

7.  Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.

Authors:  Lauren W Collison; Meenu R Pillai; Vandana Chaturvedi; Dario A A Vignali
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

8.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Authors:  Takahisa Miyao; Stefan Floess; Ruka Setoguchi; Hervé Luche; Hans Joerg Fehling; Herman Waldmann; Jochen Huehn; Shohei Hori
Journal:  Immunity       Date:  2012-02-09       Impact factor: 31.745

9.  Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.

Authors:  Adrian R Kendal; Ye Chen; Frederico S Regateiro; Jianbo Ma; Elizabeth Adams; Stephen P Cobbold; Shohei Hori; Herman Waldmann
Journal:  J Exp Med       Date:  2011-08-29       Impact factor: 14.307

10.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

Authors:  Ye Zheng; Steven Josefowicz; Ashutosh Chaudhry; Xiao P Peng; Katherine Forbush; Alexander Y Rudensky
Journal:  Nature       Date:  2010-01-13       Impact factor: 49.962
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  241 in total

1.  Anti-inflammatory or proinflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environment-dependent.

Authors:  Dongchun Liang; Aijun Zuo; Hui Shao; Mingjiazi Chen; Henry J Kaplan; Deming Sun
Journal:  J Immunol       Date:  2014-11-03       Impact factor: 5.422

Review 2.  The immunological synapse.

Authors:  Michael L Dustin
Journal:  Cancer Immunol Res       Date:  2014-11       Impact factor: 11.151

3.  Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain-Barré syndrome patients.

Authors:  Mohan S Maddur; Magalie Rabin; Pushpa Hegde; Francis Bolgert; Moneger Guy; Jean-Michel Vallat; Laurent Magy; Jagadeesh Bayry; Srini V Kaveri
Journal:  Immunol Res       Date:  2014-12       Impact factor: 2.829

4.  How regulatory T cells sense and adapt to inflammation.

Authors:  Bin Li; Song Guo Zheng
Journal:  Cell Mol Immunol       Date:  2015-08-17       Impact factor: 11.530

5.  MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor.

Authors:  Huang-Yu Yang; Joseph Barbi; Chao-Yi Wu; Ying Zheng; Paolo D A Vignali; Xingmei Wu; Jin-Hui Tao; Benjamin V Park; Shashika Bandara; Lewis Novack; Xuhao Ni; Xiaoping Yang; Kwang-Yu Chang; Ren-Chin Wu; Junran Zhang; Chih-Wei Yang; Drew M Pardoll; Huabin Li; Fan Pan
Journal:  Immunity       Date:  2016-07-19       Impact factor: 31.745

Review 6.  T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells.

Authors:  Bruce M Hall
Journal:  Clin J Am Soc Nephrol       Date:  2015-04-15       Impact factor: 8.237

7.  The Plasticity and Stability of Regulatory T Cells during Viral-Induced Inflammatory Lesions.

Authors:  Siddheshvar Bhela; Siva Karthik Varanasi; Ujjaldeep Jaggi; Sarah S Sloan; Naveen K Rajasagi; Barry T Rouse
Journal:  J Immunol       Date:  2017-07-14       Impact factor: 5.422

Review 8.  Immune regulatory cell infusion for graft-versus-host disease prevention and therapy.

Authors:  Bruce R Blazar; Kelli P A MacDonald; Geoffrey R Hill
Journal:  Blood       Date:  2018-05-04       Impact factor: 22.113

9.  Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

Authors:  Susanta Mondal; Malabendu Jana; Sridevi Dasarathi; Avik Roy; Kalipada Pahan
Journal:  Sci Signal       Date:  2018-11-27       Impact factor: 8.192

Review 10.  Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.

Authors:  Albert J Czaja
Journal:  Dig Dis Sci       Date:  2020-08-24       Impact factor: 3.199
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