Literature DB >> 23792361

Forkhead box proteins: tuning forks for transcriptional harmony.

Eric W-F Lam1, Jan J Brosens, Ana R Gomes, Chuay-Yeng Koo.   

Abstract

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.

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Year:  2013        PMID： 23792361     DOI： 10.1038/nrc3539

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  195 in total

1.  Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

Authors:  P F Dijkers; R H Medema; C Pals; L Banerji; N S Thomas; E W Lam; B M Burgering; J A Raaijmakers; J W Lammers; L Koenderman; P J Coffer
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

2.  Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

Authors:  A Brunet; J Park; H Tran; L S Hu; B A Hemmings; M E Greenberg
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

3.  The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.

Authors:  Patricia A Madureira; Rana Varshochi; Demetra Constantinidou; Richard E Francis; R Charles Coombes; Kwok-Ming Yao; Eric W-F Lam
Journal:  J Biol Chem       Date:  2006-06-28       Impact factor: 5.157

4.  Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

Authors:  Haojie Huang; Kevin M Regan; Fang Wang; Diping Wang; David I Smith; Jan M A van Deursen; Donald J Tindall
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-24       Impact factor: 11.205

5.  FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer.

Authors:  Takashi Shigekawa; Nobuhiro Ijichi; Kazuhiro Ikeda; Kuniko Horie-Inoue; Chikako Shimizu; Shigehira Saji; Kenjiro Aogi; Hitoshi Tsuda; Akihiko Osaki; Toshiaki Saeki; Satoshi Inoue
Journal:  Horm Cancer       Date:  2011-10       Impact factor: 3.869

6.  Induction of human epithelial stem/progenitor expansion by FOXM1.

Authors:  Emilios Gemenetzidis; Daniela Elena-Costea; Eric K Parkinson; Ahmad Waseem; Hong Wan; Muy-Teck Teh
Journal:  Cancer Res       Date:  2010-11-09       Impact factor: 12.701

7.  Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.

Authors:  Elizabeth Spiteri; Genevieve Konopka; Giovanni Coppola; Jamee Bomar; Michael Oldham; Jing Ou; Sonja C Vernes; Simon E Fisher; Bing Ren; Daniel H Geschwind
Journal:  Am J Hum Genet       Date:  2007-10-31       Impact factor: 11.025

8.  High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer.

Authors:  Jian Feng; Xuesong Zhang; Huijun Zhu; Xudong Wang; Songshi Ni; Jianfei Huang
Journal:  Am J Clin Pathol       Date:  2012-08       Impact factor: 2.493

9.  The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer.

Authors:  Il-Man Kim; Timothy Ackerson; Sneha Ramakrishna; Maria Tretiakova; I-Ching Wang; Tanya V Kalin; Michael L Major; Galina A Gusarova; Helena M Yoder; Robert H Costa; Vladimir V Kalinichenko
Journal:  Cancer Res       Date:  2006-02-15       Impact factor: 12.701

10.  The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells.

Authors:  Janna Krol; Richard E Francis; André Albergaria; Andrew Sunters; Andreas Polychronis; R Charles Coombes; Eric W-F Lam
Journal:  Mol Cancer Ther       Date:  2007-12       Impact factor: 6.261
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  265 in total

1.  Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

Authors:  Míriam Tarrado-Castellarnau; Roldán Cortés; Miriam Zanuy; Josep Tarragó-Celada; Ibrahim H Polat; Richard Hill; Teresa W M Fan; Wolfgang Link; Marta Cascante
Journal:  Pharmacol Res       Date:  2015-11-04       Impact factor: 7.658

2.  LncRNA-AP001631.9 promotes cell migration in gastric cancer.

Authors:  Hui Cai; Xiaojuan Ye; Bin He; Qiang Li; Yandong Li; Yong Gao
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

3.  Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle.

Authors:  Akira Wagatsuma; Masataka Shiozuka; Yuzo Takayama; Takayuki Hoshino; Kunihiko Mabuchi; Ryoichi Matsuda
Journal:  Mol Cell Biochem       Date:  2015-11-20       Impact factor: 3.396

4.  FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1.

Authors:  Yufeng Jiang; Haimin Zhang; Wei Li; Yang Yan; Xudong Yao; Wenyu Gu
Journal:  Mol Cell Biol       Date:  2020-01-16       Impact factor: 4.272

5.  A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration.

Authors:  Hui Cai; Jingde Chen; Bin He; Qiang Li; Yandong Li; Yong Gao
Journal:  Mol Cell Biochem       Date:  2015-04-24       Impact factor: 3.396

6.  Knockdown of FOXP1 promotes the development of lung adenocarcinoma.

Authors:  Hua Sheng; Xiangyang Li; Yi Xu
Journal:  Cancer Biol Ther       Date:  2018-11-08       Impact factor: 4.742

7.  Oxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling.

Authors:  Bendong Chen; Wenyan Zhou; Wenchao Zhao; Peng Yuan; Chaofeng Tang; Genwang Wang; Junzhi Leng; Jinlong Ma; Xiaowen Wang; Yongfeng Hui; Qi Wang
Journal:  Oncol Lett       Date:  2019-06-19       Impact factor: 2.967

8.  Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping.

Authors:  Exequiel Medina; Pablo Villalobos; George L Hamilton; Elizabeth A Komives; Hugo Sanabria; César A Ramírez-Sarmiento; Jorge Babul
Journal:  J Mol Biol       Date:  2020-07-28       Impact factor: 5.469

9.  FoxC1 promotes epithelial-mesenchymal transition through PBX1 dependent transactivation of ZEB2 in esophageal cancer.

Authors:  Xiaoming Zhu; Li Wei; Yangqiu Bai; Sen Wu; Shuangyin Han
Journal:  Am J Cancer Res       Date:  2017-08-01       Impact factor: 6.166

10.  Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

Authors:  Andrea E Calvert; Alexandra Chalastanis; Yongfei Wu; Lisa A Hurley; Fotini M Kouri; Yingtao Bi; Maureen Kachman; Jasmine L May; Elizabeth Bartom; Youjia Hua; Rama K Mishra; Gary E Schiltz; Oleksii Dubrovskyi; Andrew P Mazar; Marcus E Peter; Hongwu Zheng; C David James; Charles F Burant; Navdeep S Chandel; Ramana V Davuluri; Craig Horbinski; Alexander H Stegh
Journal:  Cell Rep       Date:  2017-05-30       Impact factor: 9.423
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