| Literature DB >> 22108729 |
Irving H Zucker1, Kaushik P Patel, Harold D Schultz.
Abstract
The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF. 2012 Elsevier Inc. All rights reserved.Entities:
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Year: 2012 PMID: 22108729 PMCID: PMC3224981 DOI: 10.1016/j.hfc.2011.08.007
Source DB: PubMed Journal: Heart Fail Clin ISSN: 1551-7136 Impact factor: 3.179