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Literature DB >> 30519806

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases.

Priya Balasubramanian¹, Delton Hall², Madhan Subramanian³.

Abstract

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. A clear understanding of these mechanisms will pave way for targeting the sympathetic nervous system for the treatment of cardiovascular diseases in obesity and aging.

Entities: Disease

Keywords: Aging; Cellular senescence; Hypertension; Inflammation; Leptin; Obesity; Oxidative stress; Renin-angiotensin system; Sympathetic nerve activity

Mesh：

Substances：
Leptin

Year: 2018 PMID： 30519806 PMCID： PMC6423215 DOI： 10.1007/s11357-018-0048-5

Source DB: PubMed Journal: Geroscience ISSN： 2509-2723 Impact factor: 7.713

97 in total

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Journal: J Am Coll Cardiol Date: 2002-02-20 Impact factor: 24.094

3. Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin.

Authors: J J Kuo; O B Jones; J E Hall
Journal: Hypertension Date: 2001-02 Impact factor: 10.190

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Authors: F A Dinenno; P P Jones; D R Seals; H Tanaka
Journal: Am J Physiol Heart Circ Physiol Date: 2000-04 Impact factor: 4.733

5. Leptin resistance during aging is independent of fat mass.

Authors: Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Luciano Rossetti; Nir Barzilai
Journal: Diabetes Date: 2002-04 Impact factor: 9.461

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Journal: J Clin Invest Date: 2000-05 Impact factor: 14.808

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Authors: Marcelo L G Correia; William G Haynes; Kamal Rahmouni; Donald A Morgan; William I Sivitz; Allyn L Mark
Journal: Diabetes Date: 2002-02 Impact factor: 9.461

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Journal: Hypertension Date: 2000-10 Impact factor: 10.190

9. Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus.

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Journal: Hypertension Date: 2003-08-25 Impact factor: 10.190

Review 10. Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension.

Authors: Stefan Engeli; Arya M Sharma
Journal: Curr Opin Cardiol Date: 2002-07 Impact factor: 2.161

19 in total

Review 1. The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.

Authors: Gabriela Colon; Tatiana Saccon; Augusto Schneider; Marcelo B Cavalcante; Derek M Huffman; Darlene Berryman; Ed List; Yuji Ikeno; Nicolas Musi; Andrzej Bartke; John Kopchick; James L Kirkland; Tamara Tchkonia; Michal M Masternak
Journal: Geroscience Date: 2019-09-04 Impact factor: 7.713

2. Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice.

Authors: Yoshio Hayakawa; Kenji Suita; Yoshiki Ohnuki; Yasumasa Mototani; Misao Ishikawa; Aiko Ito; Megumi Nariyama; Akinaka Morii; Kenichi Kiyomoto; Michinori Tsunoda; Ichiro Matsuo; Hiroshi Kawahara; Satoshi Okumura
Journal: J Physiol Sci Date: 2022-02-11 Impact factor: 2.781

Review 3. The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction.

Authors: Yunqiu Jiang; Andriy Yabluchanskiy; Jielin Deng; Faris A Amil; Sunny S Po; Tarun W Dasari
Journal: Geroscience Date: 2022-06-30 Impact factor: 7.581

Review 4. Obesity as a premature aging phenotype - implications for sarcopenic obesity.

Authors: Emily Nunan; Carson L Wright; Oluwayemisi A Semola; Madhan Subramanian; Priya Balasubramanian; Pamela C Lovern; Ibra S Fancher; Joshua T Butcher
Journal: Geroscience Date: 2022-04-26 Impact factor: 7.581

5. Cold Pressor Testing and Sympathetic Nervous System Contribution to Ischemia with No Obstructive Coronary Artery Disease: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project.

Authors: J Wei; L L Barsky; S Jalnapurkar; P Zarrini; G Cook-Wiens; A AlBadri; M D Nelson; C Shufelt; B Sharif; D S Berman; Lej Thomson; E M Handberg; J W Petersen; R D Anderson; C J Pepine; C N Bairey Merz; P K Mehta
Journal: Am Heart J Plus Date: 2021-12-28

6. SUMO2 regulates vascular endothelial function and oxidative stress in mice.

Authors: Young-Rae Kim; Julia S Jacobs; Qiuxia Li; Ravinder Reddy Gaddam; Ajit Vikram; Jing Liu; Modar Kassan; Kaikobad Irani; Santosh Kumar
Journal: Am J Physiol Heart Circ Physiol Date: 2019-10-04 Impact factor: 4.733

Review 7. Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication.

Authors: Gashaw Dessie; Birhanu Ayelign; Yonas Akalu; Tewodros Shibabaw; Meseret Derbew Molla
Journal: Diabetes Metab Syndr Obes Date: 2021-07-17 Impact factor: 3.168