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Literature DB >> 22106210

Occidiofungin's chemical stability and in vitro potency against Candida species.

Dayna Ellis¹, Jiten Gosai, Charles Emrick, Rachel Heintz, Lanette Romans, Donna Gordon, Shi-En Lu, Frank Austin, Leif Smith.

Abstract

Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.

Entities: Chemical Species

Mesh：

Substances：

Year: 2011 PMID： 22106210 PMCID： PMC3264235 DOI： 10.1128/AAC.05231-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

27 in total

Review 1. Echinocandin antifungal drugs.

Authors: David W Denning
Journal: Lancet Date: 2003-10-04 Impact factor: 79.321

2. Isolation and partial characterization of antibiotics produced by Paenibacillus elgii B69.

Authors: Xue-Chang Wu; Xiao-Bo Shen; Rui Ding; Chao-Dong Qian; Hai-Huan Fang; Ou Li
Journal: FEMS Microbiol Lett Date: 2010-06-16 Impact factor: 2.742

3. Biosynthesis of an antifungal oligopeptide in Burkholderia contaminans strain MS14.

Authors: Ganyu Gu; Leif Smith; Nian Wang; Hui Wang; Shi-En Lu
Journal: Biochem Biophys Res Commun Date: 2009-01-22 Impact factor: 3.575

4. Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14.

Authors: Ganyu Gu; Leif Smith; Aixin Liu; Shi-En Lu
Journal: Appl Environ Microbiol Date: 2011-07-08 Impact factor: 4.792

5. Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.

Authors: E J Ernst; M E Klepser; M A Pfaller
Journal: Antimicrob Agents Chemother Date: 2000-04 Impact factor: 5.191

6. Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs.

Authors: C Li; D Fleisher; L Li; J R Schwier; S A Sweetana; V Vasudevan; L L Zornes; L H Pao; S Y Zhou; R E Stratford
Journal: J Pharm Sci Date: 2001-01 Impact factor: 3.534

7. Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N.

Authors: Kamilia A Tawfik; Peter Jeffs; Brian Bray; George Dubay; Joseph O Falkinham; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa; Eric W Schmidt
Journal: Org Lett Date: 2010-02-19 Impact factor: 6.005

8. Micafungin: a sulfated echinocandin.

Authors: Seiji Hashimoto
Journal: J Antibiot (Tokyo) Date: 2009-01-09 Impact factor: 2.649

9. AmbR1 is a key transcriptional regulator for production of antifungal activity of Burkholderia contaminans strain MS14.

Authors: Ganyu Gu; Nian Wang; Noel Chaney; Leif Smith; Shi-En Lu
Journal: FEMS Microbiol Lett Date: 2009-05-28 Impact factor: 2.742

10. Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.

Authors: Guillermo Garcia-Effron; Samuel Lee; Steven Park; John D Cleary; David S Perlin
Journal: Antimicrob Agents Chemother Date: 2009-06-22 Impact factor: 5.191

15 in total

1. The Burkholderia contaminans MS14 ocfC gene encodes a xylosyltransferase for production of the antifungal occidiofungin.

Authors: Kuan-Chih Chen; Akshaya Ravichandran; Adam Guerrero; Peng Deng; Sonya M Baird; Leif Smith; Shi-En Lu
Journal: Appl Environ Microbiol Date: 2013-02-22 Impact factor: 4.792

Review 2. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.

Authors: Qassim Esmaeel; Maude Pupin; Philippe Jacques; Valérie Leclère
Journal: Environ Sci Pollut Res Int Date: 2017-05-25 Impact factor: 4.223

Occidiofungin's chemical stability and in vitro potency against Candida species.

Review 1. Echinocandin antifungal drugs.

2. Isolation and partial characterization of antibiotics produced by Paenibacillus elgii B69.

3. Biosynthesis of an antifungal oligopeptide in Burkholderia contaminans strain MS14.

4. Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14.

5. Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.

6. Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs.

7. Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N.

8. Micafungin: a sulfated echinocandin.

9. AmbR1 is a key transcriptional regulator for production of antifungal activity of Burkholderia contaminans strain MS14.

10. Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.

1. The Burkholderia contaminans MS14 ocfC gene encodes a xylosyltransferase for production of the antifungal occidiofungin.

Review 2. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.

3. Burkholderia as a Source of Natural Products.

4. Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.

5. Covalent Structure and Bioactivity of the Type AII Lantibiotic Salivaricin A2.

6. Formulation, Pharmacological Evaluation, and Efficacy Studies of Occidiofungin, a Novel Antifungal.

7. The presence of two cyclase thioesterases expands the conformational freedom of the cyclic Peptide occidiofungin.

8. Modifying the Lantibiotic Mutacin 1140 for Increased Yield, Activity, and Stability.

9. Antifungal activity of Brevibacillus laterosporus JX-5 and characterization of its antifungal components.

10. A Burkholderia cepacia complex non-ribosomal peptide-synthesized toxin is hemolytic and required for full virulence.